Angiotensin II (Ang II) has diverse effects on the car-diovascular system, including
vasoconstriction and aldosterone secretion, and produces positive inotropic and …

Recent studies have provided evidence that human cardiovascular tissues contain
components of the renin angiotensin system: angiotensinogen, renin, angiotensin I …

Angiotensin I-converting enzyme (ACE) inhibitors are highly effective in the treatment of
cardiovascular diseases. However, the relationship among the antihypertensive effects of …

Background—Some reports have suggested that, in vitro, human heart chymase in
homogenates contributes little to angiotensin (Ang) II formation in the presence of natural …

Recent studies have provided evidence that the human cardiovascular tissues contain
components of the renin-angiotensin system; angiotensinogen, renin, angiotensin I …

Roles of each angiotensin II producing enzymes of each of the angiotensin Il-producing
enzymes were reviewed based on experimental models. In vascular tissues, angiotensin II is …

Various organs, including the heart and blood vessels, apparently contain tissue renin-
angiotensin systems. Through autocrine and paracrine activity, locally produced angiotensin …

The justification for clinical investigation has its roots in the fact that physiological
mechanisms and disease pathogenesis in animal models replicate mechanisms and …

Objective Human chymase is a potent and specific angiotensin (Ang) II-forming serine
proteinase. Although the histological localization of heart chymase indicated that this …

Immunohistochemical studies and experiments with microdissected nephron segments
indicate that the angiotensin I converting enzyme (ACE) in the kidney is expressed in the …