Evolutionary divergence of the necroptosis effector MLKL
MC Tanzer, I Matti, JM Hildebrand, SN Young… - Cell Death & …, 2016 - nature.com
The pseudokinase, MLKL (mixed-lineage kinase domain-like), is the most terminal
obligatory component of the necroptosis cell death pathway known. Phosphorylation of the …
obligatory component of the necroptosis cell death pathway known. Phosphorylation of the …
Necrosome core machinery: MLKL
J Zhang, Y Yang, W He, L Sun - Cellular and Molecular Life Sciences, 2016 - Springer
In the study of regulated cell death, the rapidly expanding field of regulated necrosis, in
particular necroptosis, has been drawing much attention. The signaling of necroptosis …
particular necroptosis, has been drawing much attention. The signaling of necroptosis …
Insane in the membrane: a structural perspective of MLKL function in necroptosis
EJ Petrie, JM Hildebrand… - Immunology and cell …, 2017 - Wiley Online Library
Necroptosis (or 'programmed necrosis') is a caspase‐independent cell death pathway that
operates downstream of death receptors, including Tumour Necrosis Factor Receptor‐1 …
operates downstream of death receptors, including Tumour Necrosis Factor Receptor‐1 …
[HTML][HTML] MLKL, the protein that mediates necroptosis, also regulates endosomal trafficking and extracellular vesicle generation
Activation of the pseudokinase mixed lineage kinase domain-like (MLKL) upon its
phosphorylation by the protein kinase RIPK3 triggers necroptosis, a form of programmed cell …
phosphorylation by the protein kinase RIPK3 triggers necroptosis, a form of programmed cell …
MLKL regulates necrotic plasma membrane permeabilization
Recent data from two independent laboratories have shed new light on the molecular
mechanisms by which mixed lineage kinase domainlike (MLKL) promotes a peculiar form of …
mechanisms by which mixed lineage kinase domainlike (MLKL) promotes a peculiar form of …
Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators
Necroptosis is a form of programmed necrosis that is mediated by various cytokines and
pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes …
pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes …
RIPK3 activation leads to cytokine synthesis that continues after loss of cell membrane integrity
Necroptosis is a form of programmed cell death that is defined by activation of the kinase
RIPK3 and subsequent cell membrane permeabilization by the effector MLKL. RIPK3 …
RIPK3 and subsequent cell membrane permeabilization by the effector MLKL. RIPK3 …
Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop
The pseudokinase MLKL (mixed lineage kinase domain-like), has recently emerged as a
critical component of the necroptosis cell death pathway. Although it is clear that …
critical component of the necroptosis cell death pathway. Although it is clear that …
RIPK 3 in cell death and inflammation: the good, the bad, and the ugly
S Orozco, A Oberst - Immunological reviews, 2017 - Wiley Online Library
Necroptosis is a form of cell death that can be observed downstream of death receptor or
pattern recognition receptor signaling under certain cellular contexts, or in response to some …
pattern recognition receptor signaling under certain cellular contexts, or in response to some …
Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis
M Rübbelke, D Fiegen, M Bauer… - Proceedings of the …, 2020 - National Acad Sciences
As an alternative pathway of controlled cell death, necroptosis can be triggered by tumor
necrosis factor via the kinases RIPK1/RIPK3 and the effector protein mixed-lineage kinase …
necrosis factor via the kinases RIPK1/RIPK3 and the effector protein mixed-lineage kinase …