The pseudokinase, MLKL (mixed-lineage kinase domain-like), is the most terminal
obligatory component of the necroptosis cell death pathway known. Phosphorylation of the …

In the study of regulated cell death, the rapidly expanding field of regulated necrosis, in
particular necroptosis, has been drawing much attention. The signaling of necroptosis …

Necroptosis (or 'programmed necrosis') is a caspase‐independent cell death pathway that
operates downstream of death receptors, including Tumour Necrosis Factor Receptor‐1 …

Activation of the pseudokinase mixed lineage kinase domain-like (MLKL) upon its
phosphorylation by the protein kinase RIPK3 triggers necroptosis, a form of programmed cell …

Recent data from two independent laboratories have shed new light on the molecular
mechanisms by which mixed lineage kinase domainlike (MLKL) promotes a peculiar form of …

Necroptosis is a form of programmed necrosis that is mediated by various cytokines and
pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes …

Necroptosis is a form of programmed cell death that is defined by activation of the kinase
RIPK3 and subsequent cell membrane permeabilization by the effector MLKL. RIPK3 …

The pseudokinase MLKL (mixed lineage kinase domain-like), has recently emerged as a
critical component of the necroptosis cell death pathway. Although it is clear that …

Necroptosis is a form of cell death that can be observed downstream of death receptor or
pattern recognition receptor signaling under certain cellular contexts, or in response to some …

As an alternative pathway of controlled cell death, necroptosis can be triggered by tumor
necrosis factor via the kinases RIPK1/RIPK3 and the effector protein mixed-lineage kinase …