Receptor interacting protein kinase 3 (RIPK3) is an essential serine/threonine kinase for
necroptosis, a type of regulated necrosis. A variety of stimuli can cause RIPK3 activation …

Over the past few decades, mechanisms of programmed cell death have attracted the
scientific community because they are involved in diverse human diseases. Initially …

Necroptosis is a caspase-independent form of cell death that is triggered by activation of the
receptor interacting serine/threonine kinase 3 (RIPK3) and phosphorylation of its …

Recently, necroptosis, as a programmed cell death pathway, has drawn much attention as it
has been implicated in multiple pathologies, especially in the field of inflammatory diseases …

The pseudokinase mixed lineage kinase domain-like protein (MLKL) is a key component of
tumor necrosis factor (TNF)-induced necroptosis and plays a crucial role in necroptosis …

A signaling pathway that induces programmed necrotic cell death (necroptosis) was
reported to be activated in cells by several cytokines and various pathogen components …

Necroptosis, or regulated necrosis, is an important type of programmed cell death in addition
to apoptosis. Necroptosis induction leads to cell membrane disruption, inflammation and …

Phosphorylation of the MLKL pseudokinase by the RIPK3 kinase leads to MLKL
oligomerization, translocation to, and permeabilization of, the plasma membrane to induce …

Programmed cell death has a vital role in embryonic development and tissue homeostasis.
Necroptosis is an alternative mode of regulated cell death mimicking features of apoptosis …

Necroptosis is a form of regulated necrosis controlled by receptor-interacting kinase 1
(RIPK1 or RIP1), RIPK3 (RIP3), and pseudokinase mixed lineage kinase domain-like protein …