The inflammatory signal adaptor RIPK3: functions beyond necroptosis
K Moriwaki, FKM Chan - International review of cell and molecular biology, 2017 - Elsevier
Receptor interacting protein kinase 3 (RIPK3) is an essential serine/threonine kinase for
necroptosis, a type of regulated necrosis. A variety of stimuli can cause RIPK3 activation …
necroptosis, a type of regulated necrosis. A variety of stimuli can cause RIPK3 activation …
[HTML][HTML] Necroptosis: a pathogenic negotiator in human diseases
Over the past few decades, mechanisms of programmed cell death have attracted the
scientific community because they are involved in diverse human diseases. Initially …
scientific community because they are involved in diverse human diseases. Initially …
[HTML][HTML] RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury
K Newton, DL Dugger, A Maltzman, JM Greve… - Cell Death & …, 2016 - nature.com
Necroptosis is a caspase-independent form of cell death that is triggered by activation of the
receptor interacting serine/threonine kinase 3 (RIPK3) and phosphorylation of its …
receptor interacting serine/threonine kinase 3 (RIPK3) and phosphorylation of its …
[HTML][HTML] MLKL: Functions beyond serving as the Executioner of Necroptosis
Recently, necroptosis, as a programmed cell death pathway, has drawn much attention as it
has been implicated in multiple pathologies, especially in the field of inflammatory diseases …
has been implicated in multiple pathologies, especially in the field of inflammatory diseases …
[HTML][HTML] Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis
XM Zhao, Z Chen, JB Zhao, PP Zhang, YF Pu… - Cell death & …, 2016 - nature.com
The pseudokinase mixed lineage kinase domain-like protein (MLKL) is a key component of
tumor necrosis factor (TNF)-induced necroptosis and plays a crucial role in necroptosis …
tumor necrosis factor (TNF)-induced necroptosis and plays a crucial role in necroptosis …
[HTML][HTML] Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it
S Yoon, K Bogdanov, A Kovalenko… - Cell Death & …, 2016 - nature.com
A signaling pathway that induces programmed necrotic cell death (necroptosis) was
reported to be activated in cells by several cytokines and various pathogen components …
reported to be activated in cells by several cytokines and various pathogen components …
[HTML][HTML] Molecular insights into the mechanism of necroptosis: the necrosome as a potential therapeutic target
J Chen, R Kos, J Garssen, F Redegeld - Cells, 2019 - mdpi.com
Necroptosis, or regulated necrosis, is an important type of programmed cell death in addition
to apoptosis. Necroptosis induction leads to cell membrane disruption, inflammation and …
to apoptosis. Necroptosis induction leads to cell membrane disruption, inflammation and …
[HTML][HTML] Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
Phosphorylation of the MLKL pseudokinase by the RIPK3 kinase leads to MLKL
oligomerization, translocation to, and permeabilization of, the plasma membrane to induce …
oligomerization, translocation to, and permeabilization of, the plasma membrane to induce …
[HTML][HTML] Necroptosis: a regulated inflammatory mode of cell death
YK Dhuriya, D Sharma - Journal of neuroinflammation, 2018 - Springer
Programmed cell death has a vital role in embryonic development and tissue homeostasis.
Necroptosis is an alternative mode of regulated cell death mimicking features of apoptosis …
Necroptosis is an alternative mode of regulated cell death mimicking features of apoptosis …
[HTML][HTML] Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis
J Hou, J Ju, Z Zhang, C Zhao, Z Li, J Zheng… - Cell death & …, 2019 - nature.com
Necroptosis is a form of regulated necrosis controlled by receptor-interacting kinase 1
(RIPK1 or RIP1), RIPK3 (RIP3), and pseudokinase mixed lineage kinase domain-like protein …
(RIPK1 or RIP1), RIPK3 (RIP3), and pseudokinase mixed lineage kinase domain-like protein …