Combination antibiotic therapy for invasive infections with Gram-negative bacteria is
employed in many health care facilities, especially for certain subgroups of patients …

Therapy with antimicrobial combinations has been used as long as antimicrobials have
been available. Combinations of antibiotics are often used to take advantage of different …

Whether combination antimicrobial therapy is more efficacious than monotherapy for gram-
negative bacteraemia remains controversial. Although there are theoretical advantages to …

Combination antibiotic therapy for Gram-negative sepsis is controversial. The present review
provides a brief summary of the existing knowledge on combination therapy for severe …

Widespread emergence of multidrug resistant (MDR) bacterial pathogens is a problem of
global dimension. MDR infections are difficult to treat and frequently associated with high …

Infections caused by carbapenemase-producing, multidrug-resistant (MDR), or extensively
drug-resistant (XDR) Gram-negative bacteria constitute a major therapeutic challenge …

The use of combination antimicrobial therapy for bacteraemia caused by Gram-negative
bacilli is controversial. We did a meta-analysis of published studies to determine whether a …

The use of combination antibiotic therapy for severe pseudomonal infections is a standard
practice in many hospitals; however, the data supporting its use are somewhat unclear …

Antimicrobial combinations are used widely, although most infections in patients with normal
defenses can be treated with a single antimicrobial agent. Few reasons justify the use of …

tients with undefined bacterial infection;(b) to treat mixed bacterial infections, the
components of which may not have a common antibiotic susceptibility;(c) to prevent the …