Objectives: Cyclosporine (CsA) has a narrow thera-peutic range, and its pharmacokinetic
characteristics vary among individuals. It also is a substrate for cytochrome P450 (CYP) 3A …

Background The immunosuppressive drug cyclosporine (INN, ciclosporin), whose
pharmacokinetic characteristics vary greatly among individuals, is a substrate for …

Objective The objective of this study was to retrospectively evaluate the effects of MDR1,
CYP3A4* 18B, and CYP3A5* 3 genetic polymorphisms on cyclosporine A (CsA) …

SUMMARY 1 The calcineurin inhibitor cyclosporine is widely used to prevent allograft
rejection after solid organ transplantation. It has a narrow therapeutic index and shows …

Advances in immunosuppressive therapy allowed renal transplantation to become the
treatment of choice for suitable candidates with (end stage renal disease) ESRD. The post …

Aim: To evaluate retrospectively the association of cytochrome P450 3A (CYP3A) and ATP-
binding cassette sub-family B member 1 (ABCB1) gene polymorphisms with the …

Background: A substantial proportion of the variability in the absorption and clearance of
cyclosporin A (CsA) after oral administration has been attributed to variability in liver …

Background Immunosuppressive drugs such as cyclosporine A (CsA) are characterized by a
narrow therapeutic range and high interindividual pharmacokinetic variations. Therefore, the …

Objective The aim of this study was to assess the influence of the cytochrome (CYP450) 3A5
and multidrug resistance (MDR1) gene polymorphisms on cyclosporine A (CsA) trough …

Cyclosporine is a substrate of cytochrome P-450 3A (CYP3A) subfamily of enzymes and
characterized by a narrow therapeutic range with wide interindividual variation in …