PDGF‐AA guides cell crosstalk between human dental pulp stem cells in vitro via the PDGFR‐α/PI3K/Akt axis

S Xu, J Wei, Y Liu, L Zhang, M Duan, J Li… - International …, 2024 - Wiley Online Library
Aim To explore the influence of PDGF‐AA on cell communication between human dental
pulp stem cells (DPSCs) by characterizing gap junction intercellular communication (GJIC) …

Connexin43-containing gap junctions potentiate extracellular Ca2+-induced odontoblastic differentiation of human dental pulp stem cells via Erk1/2

S Li, H He, G Zhang, F Wang, P Zhang, Y Tan - Experimental cell research, 2015 - Elsevier
Extracellular Ca 2+ can promote dentin sialophosphoprotein (DSPP) expression and
odontoblastic differentiation of dental pulp stem cells (DPSCs). Gap junctions mediated by …

Single-cell RNA sequencing reveals vascularization-associated cell subpopulations in dental pulp: PDGFRβ+ DPSCs with activated PI3K/AKT pathway

T Di, L Wang, B Cheng, M Guo, C Feng, Z Wu… - Stem Cells, 2024 - academic.oup.com
Background This study aims to address challenges in dental pulp regeneration therapy. The
heterogeneity of DPSCs poses challenges, especially in stem cell transplantation for clinical …

IGFBP5 enhances the dentinogenesis potential of dental pulp stem cells via JNK and ErK signalling pathways

J Hao, H Yang, Y Cao, C Zhang… - Journal of Oral …, 2020 - Wiley Online Library
Background Dental stem cell transplantation has become a new method for tooth tissue
regeneration. However, its molecular mechanism of the dentinogenic differentiation is still …

The effects of platelet-derived growth factor-BB on human dental pulp stem cells mediated dentin-pulp complex regeneration

M Zhang, F Jiang, X Zhang, S Wang… - Stem Cells …, 2017 - academic.oup.com
Dentin-pulp complex regeneration is a promising alternative treatment for the irreversible
pulpitis caused by tooth trauma or dental caries. This process mainly relies on the …

[HTML][HTML] PDGFRβ+/c-kit+ pulp cells are odontoblastic progenitors capable of producing dentin-like structure in vitro and in vivo

S Cai, W Zhang, W Chen - BMC Oral Health, 2016 - Springer
Background Successful pulp regeneration depends on identification of pulp stem cells
capable of differentiation under odontoblastic lineage and producing pulp-dentinal like …

IGFBP5 promotes angiogenic and neurogenic differentiation potential of dental pulp stem cells

J Li, S Diao, H Yang, Y Cao, J Du… - Development, Growth & …, 2019 - Wiley Online Library
Dental stem cells for dental pulp regeneration have become a new strategy for pulpitis
treatment. Angiogenesis and neurogenesis play a vital role in the pulp‐dentin complex …

Dental pulp stem cell migration

C Howard, PE Murray, KN Namerow - Journal of endodontics, 2010 - Elsevier
INTRODUCTION: The purpose of this in vitro study was to investigate the migration of dental
pulp stem cells (DPSCs) in response to chemotactants and extracellular matrix proteins …

[HTML][HTML] PDGF-BB signaling via PDGFR-β regulates the maturation of blood vessels generated upon vasculogenic differentiation of dental pulp stem cells

Z Zhang, KA Warner, A Mantesso… - Frontiers in Cell and …, 2022 - frontiersin.org
A functional vascular network requires that blood vessels are invested by mural cells. We
have shown that dental pulp stem cells (DPSC) can undergo vasculogenic differentiation …

PDGF-BB, NGF and BDNF enhance pulp-like tissue regeneration via cell homing

L Li, Z Wang - RSC advances, 2016 - pubs.rsc.org
In this study, we investigated the cytobiological effects of platelet-derived growth factor BB
(PDGF-BB), nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) on the …