Analysis of salsolinol and salsoline in biological samples using deuterium-labelled internal standards and gas chromatography—mass spectrometry

B Sjöquist, E Magnuson - … of Chromatography B: Biomedical Sciences and …, 1980 - Elsevier
Salsolinol and salsoline were labelled with deuterium using an acidic exchange reaction in
2 HCl 2 H 2 O. Two deuterium atoms were incorporated in both compounds. The …

Identification and quantification of 1-carboxysalsolinol and salsolinol in biological samples by gas chromatography—mass spectrometry

B Sjöquist, C Ljungquist - … of Chromatography B: Biomedical Sciences and …, 1985 - Elsevier
Carboxysalsolinol was found to be present in rat striatum, human urine and caudate nucleus
of post mortem human brain, according to capillary column gas chromatographic retention …

[引用][C] Analysis of salsolinol in human brain using high-performance liquid chromatography with electrochemical detection

T Sasaoka, N Kaneda, T Niwa, Y Hashizume… - … of Chromatography B …, 1988 - Elsevier
Catecholamines and aldehydes are known to undergo a Pictet-Spengler type condensation
to form tetrahydroisoquinolines [11. One of the most extensively studied condensation …

[引用][C] Rat brain salsolinol and blood-brain barrier

T Origitano, J Hannigan, MA Collins - Brain research, 1981 - Elsevier
The 6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline (TIQ), salsolinol, is a substantial
constituent along with its mono-O-methylated metabolite (s) in urine obtained from alcoholic …

Gas chromatographic/mass spectrometric methodology for simultaneous assay of salsolinol, dopamine, norepinephrine, dihydroxyphenylacetic acid and …

MW Duncan, GA Smythe… - Biomedical mass …, 1985 - Wiley Online Library
Abstract Synthesis of deuterated (2H4) salsolinol from (2H4) dopamine via a Pictet‐
Spengler condensation is described. This (2H4) salsolinol is an ideal internal standard to …

Detection of endogenous salsolinol in neonatal rat tissue by a radioenzymatic—thin-layer chromatographic assay

CA Nesterick, RG Rahwan - Journal of Chromatography B: Biomedical …, 1979 - Elsevier
A sensitive radioenzymatic—thin-layer chromatographic assay for the quantitative analysis
of the tetrahydroisoquinoline alkaloid, salsolinol, in plasma and neonatal rat tissue is …

[HTML][HTML] Salsolinol: an unintelligible and double-faced molecule—lessons learned from in vivo and in vitro experiments

M Kurnik-Łucka, P Panula, A Bugajski, K Gil - Neurotoxicity Research, 2018 - Springer
Abstract Salsolinol (1-methyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline) is a
tetrahydroisoquinoline derivative whose presence in humans was first detected in the urine …

Determination of the enantiomeric composition of salsolinol in biological samples by high-performance liquid chromatography with electrochemical detection

E Pianezzola, V Bellotti, E Fontana, E Moro… - … of Chromatography B …, 1989 - Elsevier
The enantiomers of salsolinol were completely separated as diastereoisomeric derivatives,
after reaction with S-1-(1-naphthyl) ethyl isothiocyanate, by reversed-phase high …

Influence of food intake on the enantiomeric composition of urinary salsolinol in man

M Strolin Benedetti, P Dostert, P Carminati - Journal of Neural …, 1989 - Springer
Salsolinol is present in human fluids and tissues as well as in foods and beverages. It was
shown previously that the R enantiomer of salsolinol predominates in human urine, whereas …

Plasma and urine salsolinol in humans: effect of acute ethanol intake on the enantiomeric composition of salsolinol

H Haber, A Winkler, I Putscher… - Alcoholism: Clinical …, 1996 - Wiley Online Library
The tetrahydroisoquinoline (TIQ) salsolinol (SAL), a condensation product of dopamine and
pyruvate or acetaldehyde, is one of the neuropharmacologically active alkaloids in …