Hypoxia-inducible factor (HIF) is a set of transcription factors that regulate the cellular
response to hypoxia. There is a great body of evidence supporting the protective role of HIF …

Cardiac function is required for blood circulation and systemic oxygen delivery. However,
the heart has intrinsic oxygen demands that must be met to maintain effective contractility …

Hypoxia inducible factor (HIF) is an oxygen-sensitive transcription factor that enables
aerobic organisms to adapt to hypoxia. This is achieved through the transcriptional …

Myocardial infarction (MI), an acute cardiovascular disease characterized by coronary artery
blockage, inadequate blood supply, and subsequent ischemic necrosis of the myocardium …

Since its discovery in early 1990s, hypoxia inducible factor 1 (HIF-1) has been increasingly
recognized for its key role in transcriptional control of more than a hundred genes that …

Cardiovascular disease (CVD) accounts for the largest number of deaths worldwide,
necessitating the development of novel treatments and prevention strategies. Given the …

The hypoxia-inducible factor (HIF) system was discovered as an oxygen-sensitive regulatory
pathway that confers adaptive responses to hypoxia. Novel aspects of this growing network …

Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular
diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main …

The hypoxia-inducible transcription factor HIF is induced early in acute myocardial ischemia
in humans, but it is unknown whether this activation of HIF persists during chronic heart …

The circulatory system distributes blood flow to each tissue and transports oxygen and
nutrients. Peripheral circulation is required to maintain the physiological function in each …