Aims The hypoxia-inducible factor-1 (HIF-1) is the master modulator of hypoxic gene
expression. The effects of chronically stabilized cardiac HIF-1α and its role in the diseased …

Hypoxia plays a fundamental role in the pathophysiology of common causes of mortality,
including ischemic heart disease, stroke, cancer, chronic lung disease, and congestive heart …

Oxygen is essential for living organisms. Molecular oxygen binds to hemoglobin and is
delivered to every organ in the body. In several cardiovascular diseases or anemia, local …

Hypoxia-inducible factor-1 (HIF-1) is a nuclear transcription factor that is upregulated in
hypoxia and coordinates the adaptive response to hypoxia by driving the expression of over …

Abstract Hypoxia-inducible factors (HIF)-1 and HIF-2 are master regulators of oxygen
homeostasis that regulate the expression of thousands of genes in order to match O2 supply …

Hypoxia-inducible factor 1 (HIF-1) is a basic-helix-loop-helix transcription factor that plays
essential roles in mammalian development and physiology. HIF-1 is a heterodimer …

In most cell types a family of transcriptional regulatory proteins termed hypoxia-inducible
factors, of which HIF-1 is the most prevalent, mediates the physiologic response to hypoxia …

During the past several years much new evidence has accumulated regarding the molecular
and biochemical mechanisms underlying cardiac responses to hypoxia and to …

The heart forms early in development and delivers oxygenated blood to the rest of the
embryo. After birth, the heart requires kilograms of ATP each day to support contractility for …

Objectives: The aim of this research was to test whether constitutive expression of hypoxia-
inducible factor 1-alpha (HIF-1α) influences infarction size and cardiac performance after …