Oxygen plays a critical role in the perpetuation and propagation of almost all forms of life.
The primary site of cellular oxygen consumption is the mitochondrial electron transport chain …

Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional
induction of a series of genes that participate in angiogenesis, iron metabolism, glucose …

Background Hypoxia inducible factor-1 (HIF-1) is a transcription factor that functions to
maintain cellular homeostasis in response to hypoxia. There is evidence that HIF-1 can also …

Hypoxia inducible factors (HIFs) are α/β heterodimeric transcription factors that direct
multiple cellular and systemic responses in response to changes in oxygen availability. The …

Human cells require O2 for many metabolic processes, most notably oxidative
phosphorylation, the major source of ATP generation, and hypoxia plays a significant …

Hypoxia-inducible factor (HIF) is a dimeric transcription factor identified as the major
regulator of hypoxic responses in cells. Its activity is mainly regulated by protein stability. In …

Cellular responses to oxygen are increasingly recognized as critical in normal development
and physiology, and are implicated in pathological processes. Many of these responses are …

Abstract Hypoxia-inducible factor (HIF)-1α and-2α have diverse actions on the myocardium,
but the importance of direct effects on cardiac myocytes is unclear. To define their regional …

Contractile failure of myocardial cells is a common cause of mortality in ischemic heart
disease. In response to hypoxic conditions, cells upregulate the activity of hypoxia-inducible …

Hypoxia is an inadequate oxygen supply to tissues and cells, which can restrict their
function. The hypoxic response is primarily mediated by the hypoxia-inducible transcription …