Atherosclerosis is by far the most frequent underlying cause of coronary artery disease,
carotid artery disease and peripheral arterial disease, and is associated with high morbidity …

Hypoxia-Inducible Factor-1 (HIF-1) is a transcription factor which is activated by hypoxia and
involved in the adaptative response of the cell to oxygen deprivation. During hypoxic stress …

Hypoxia is a state where oxygen availability/delivery is below the level necessary to
maintain physiological oxygen tension for a particular tissue. It is well-established that when …

The heterodimeric hypoxia‐inducible factor (HIF)‐1 is a master transcriptional regulator of
oxygen homeostasis and a possible target for gene therapy of ischemic disease. Although …

Aim: We sought to determine whether hypoxia signaling mediated by the hypoxia-inducible
factor 1 or 2 (HIF1A or HIF2A) underlies the proliferation phenotype that is induced by …

Oxygen maintains the homeostasis of an organism in a delicate balance in different tissues
and organs. Under hypoxic conditions, hypoxia-inducible factors (HIFs) are specific and …

Angiogenesis, a process that leads to the formation of new blood vessels, from a existing
network of vessels is tightly regulated. The understanding of mechanisms that control its …

The hypoxia-inducible factor (HIF) family has three distinct members in most vertebrates. All
three HIFs consist of a unique and oxygen-labile α-subunit and a common and stable β …

Abstract Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master
regulator of oxygen homeostasis. HIF-1 regulates the expressions of the proteins that …

Hypoxia-inducible factor (HIF) is a transcriptional activator that coordinates adaptive
responses to hypoxia. An increased activity is recognized in the majority of clinical relevant …