Although the locations of promoters and enhancers have been identified in several cell
types, we still have limited information on their connectivity. We developed HiCap, which …

Enhancer is a positive regulator for spatiotemporal development in eukaryotes. As a cluster,
super‐enhancer is closely related to cell identity‐and fate‐determined processes. Both of …

Developmental progression is driven by specific spatiotemporal domains of gene
expression, which give rise to stereotypically patterned embryos even in the presence of …

Enhancers can regulate the promoters of their target genes over very large genomic
distances. It is widely assumed that mechanisms of enhancer action involve the …

Developmental genes can have complex cis-regulatory regions with multiple enhancers.
Early work revealed remarkable modularity of enhancers, whereby distinct DNA regions …

Metazoan chromosomes are sequentially partitioned into topologically associating domains
(TADs) and then into smaller sub-domains. One class of sub-domains, insulated …

The organization of the genome in the nucleus and the interactions of genes with their
regulatory elements are key features of transcriptional control and their disruption can cause …

Long-range cis-regulatory elements such as enhancers coordinate cell-specific
transcriptional programmes by engaging in DNA looping interactions with target promoters …

In this review, we look at the most recent studies of DNA elements that function over long
genomic distances to regulate gene transcription and will discuss the mechanisms genes …

Mammalian embryogenesis commences with two pivotal and binary cell fate decisions that
give rise to three essential lineages: the trophectoderm, the epiblast and the primitive …