Amiodarone, verapamil, and quinidine do not affect equilibrium binding of digoxin
RA Colvin, TF Ashavaid, AM Katz… - Journal of …, 1990 - journals.lww.com
The binding of [3H] digoxin to purified canine cardiac sarcolemmal vesicles was
characterized. Scatchard analysis of saturation isotherms yielded linear plots with a maximal …
characterized. Scatchard analysis of saturation isotherms yielded linear plots with a maximal …
Digoxin-Verapamil Interaction: In Vitro: Studies in Rat Tissue
G Koren, S Soldin, SM MacLeod - Journal of Cardiovascular …, 1983 - journals.lww.com
Recent studies have shown a significant increase in plasma digoxin concentration during
verapamil treatment. This phenomenon has been attributed in part to reduced renal …
verapamil treatment. This phenomenon has been attributed in part to reduced renal …
Effect of quinidine on the digoxin receptor in vitro.
WJ Ball, D Tse-Eng, ET Wallick… - The Journal of …, 1981 - Am Soc Clin Investig
To investigate the basis for a clinically important digitalis-quinidine interaction that is
characterized by increases in serums digoxin concentrations when quinidine is …
characterized by increases in serums digoxin concentrations when quinidine is …
Altered tissue digoxin uptake after a toxic dose.
K Taubert, W Shapiro - Recent Advances in Studies on Cardiac …, 1975 - europepmc.org
Tissue distribution and left ventricular (LV) effects of digoxin were studied after intravenous
administration of low and high doses to dogs. LV dP/dt was increased by 0.03 mg/kg digoxin …
administration of low and high doses to dogs. LV dP/dt was increased by 0.03 mg/kg digoxin …
[引用][C] Effects of benzodiazepines on digoxin tissue concentrations and plasma protein binding
JR Castillo-Ferrando, AC Prieto… - Journal of Pharmacy …, 1983 - academic.oup.com
Methods Bound and unbound digoxin plasma levels were determined in-vitro, in a control
human plasma containing 2.5 x 1CW M (2 ng ml-1) of digoxin to which 1 and 3 pg ml-1 were …
human plasma containing 2.5 x 1CW M (2 ng ml-1) of digoxin to which 1 and 3 pg ml-1 were …
Prazosin alters free and total plasma digoxin levels in dogs
LM Plunkett, RD Gokhale, JJ Vallner, RL Tackett - American Heart Journal, 1985 - Elsevier
Digoxin has been associated with a variety of drug interactions. Studies in our laboratory
indicate that single doses of prazosin may alter plasma steady-state digoxin levels. Adult …
indicate that single doses of prazosin may alter plasma steady-state digoxin levels. Adult …
Myocardial distribution of digoxin and renal function
WJ Jusko, M Weintraub - Clinical Pharmacology & …, 1974 - Wiley Online Library
Digoxin concentmtions in serum and left ventricular tissue were measured at autopsy and
related to estimated antemortem creatinine clearances in 15 patients. A significant …
related to estimated antemortem creatinine clearances in 15 patients. A significant …
Transient changes in plasma digoxin concentration and the development of cardiotoxicity.
DJ Chapple, R Hughes, BF Johnson - British Journal of …, 1977 - ncbi.nlm.nih.gov
Eight dogs were given two infusions of digoxin 0.1 mg/kg, one over 9 min and the other one
over 90 min in a randomized sequence, allowing at least 12 days between each experiment …
over 90 min in a randomized sequence, allowing at least 12 days between each experiment …
Effects of selected drugs on serum digoxin concentration in dogs
RD Wilkerson, PB Mockridge, GK Massing - The American Journal of …, 1980 - Elsevier
The effects of quinidine, quinine, aspirin, ibuprofen, indomethacin and acetaminophen on
steady state serum digoxin concentrations and total body digoxin clearance were studied in …
steady state serum digoxin concentrations and total body digoxin clearance were studied in …
Relationship of serum and myocardial digoxin concentration to electrocardiographic estimation of digoxin intoxication.
TL Biddle, M Weintraub, L Lasagna - Journal of Clinical …, 1978 - europepmc.org
Serum and myocardial digoxin levels were studied in 18 patients who came to autopsy. An
independent analysis of electrocardiograms prior to death was made to ascertain the …
independent analysis of electrocardiograms prior to death was made to ascertain the …