Problems in studying pharmacokinetic interactions with digoxin were evaluated using as a
test model the examination of a possible interaction between digoxin and ethmozine in a …

Abstract 1 Twenty-nine dogs were given digoxin (0.25 mg) by mouth twice daily for eight
days. Some of them (group 1) also received diuretics and others (group 2) a …

The protein binding of digoxin in human serum was investigated using equilibrium dialysis
and tritium-labelled digoxin. A constant protein bound fraction of about 30% was found over …

Of the several glycosides available for treating heart disease, digoxin has found most favour
in Britain. All these drugs have a narrow therapeutic index, and intoxication occurs in 10 …

Quinidine elevates serum digoxin concentration in part by reducing the volume of
distribution of digoxin, which implies that quinidine displaces digoxin from tissues. The …

Nine healthy male volunteers received single 0.5, 1.0, and 1.5 mg. doses of intravenous
digoxin in a randomized three-way crossover study. Multiple venous blood samples were …

Cardiotoxicity remains a significant problem limiting the clinical usefulness of the cardiac
glycosides. Many recent studies have demonstrated that patients showing clear evidence of …

The effects of the digoxin‐quinidine interaction on cardiac function was examined in healthy
subjects. Our results indicate that while serum digoxin levels were elevated, the improved …

About 70 to 80% of an oral dose of digoxin is absorbed, mainly in the proximal part of the
small intestine. The degree of binding to serum albumin is 20 to 30%. Digoxin is extensively …

The digoxin-quinidine interaction was studied in nine healthy human subjects aged 26 to 31
years. A single oral dose (400 mg) of quinidine sulfate administered to subjects taking …