Further insights into digoxin-quinidine interaction: lack of correlation between serum digoxin concentration and inotropic state of the heart
PD Hirsh, HJ Weiner, RL North - The American Journal of Cardiology, 1980 - Elsevier
The digoxin-quinidine interaction was studied in nine healthy human subjects aged 26 to 31
years. A single oral dose (400 mg) of quinidine sulfate administered to subjects taking …
years. A single oral dose (400 mg) of quinidine sulfate administered to subjects taking …
The electrophysiologic effects of low and high digoxin concentrations on isolated mammalian cardiac tissue: reversal by digoxin-specific antibody
WJ Mandel, JT Bigger, VP Butler - The Journal of Clinical …, 1972 - Am Soc Clin Investig
The effects of digoxin on electrophysiologic properties were evaluated in isolated perfused
cardiac tissue. In canine Purkinje fiber (PF)-ventricular muscle (VM) preparations, control …
cardiac tissue. In canine Purkinje fiber (PF)-ventricular muscle (VM) preparations, control …
The effect of nifedipine on serum digoxin concentrations in patients
JB Schwartz, A Raizner, S Akers - American Heart Journal, 1984 - Elsevier
Drug interactions with digoxin are being increasingly recognized. Some calcium antagonists
have been shown to alter digoxin kinetics and changes in digoxin dosage have been …
have been shown to alter digoxin kinetics and changes in digoxin dosage have been …
Subcellular distribution of digoxin-H3 in isolated guinea-pig and rat hearts
S Dutta, S Goswami, JO Lindower, BH Marks - Journal of Pharmacology and …, 1968 - ASPET
Guinea-pig and rat hearts were perfused via the aorta at constant flow with 10-7 M digoxin-
H3 for periods up to 64 min. The temperature was 28° C. The hearts were then perfused for …
H3 for periods up to 64 min. The temperature was 28° C. The hearts were then perfused for …
The relationship between cardiotoxicity and plasma digoxin concentration in conscious dogs.
DJ Chapple, R Hughes, BF Johnson - British Journal of …, 1976 - ncbi.nlm.nih.gov
Abstract 1 The tendency of a given oral dose of digoxin to induce cardiac dysrhythmia was
determined indirectly at various times after its administration to eight conscious dogs by …
determined indirectly at various times after its administration to eight conscious dogs by …
Pharmacokinetics of digoxin in patients with acute myocardial infarction
UR Korhonen, AJ Jounela, AJ Pakarinen… - The American Journal of …, 1979 - Elsevier
The effects of acute myocardial infarction on the pharmacqkinetics of digoxin were studied.
Digoxin, 0.75 mg, was given orally to 12 patients with left-sided cardiac failure due to acute …
Digoxin, 0.75 mg, was given orally to 12 patients with left-sided cardiac failure due to acute …
Cardiac effects of treatment with quinidine and digoxin, alone and in combination
K Schenck-Gustafsson, T Jogestrand, LÅ Brodin… - The American Journal of …, 1983 - Elsevier
Systolic time intervals (QS 2-I and LVET-I) and echocardiographically determined ejection
fraction and velocity of circumferential fiber shortening were recorded in 10 healthy …
fraction and velocity of circumferential fiber shortening were recorded in 10 healthy …
Quinidine-digoxin interaction: Pharmacokinetics, underlying mechanism and clinical implications
W Doering - New England Journal of Medicine, 1979 - Mass Medical Soc
Administration of quinidine with digoxin increased serum digoxin concentrations in 79
patients and five volunteers. In 38 patients on a constant glycoside maintenance dose, the …
patients and five volunteers. In 38 patients on a constant glycoside maintenance dose, the …
Drug interactions with digoxin
DD Brown, R Spector, RP Juhl - Drugs, 1980 - Springer
Multiple drug administration may affect the actions of digoxin either by altering its myocardial
effects (dose-response relationship or pharmacodynamic effect) or by altering the …
effects (dose-response relationship or pharmacodynamic effect) or by altering the …