The effect of diltiazem on digoxin serum concentration was evaluated in 9 patients who had
been treated chronically for heart disease with digoxin, 0.25 mg/day. The indications for …

Diltiazem has been reported to decrease or not to affect digoxin elimination. The effects of
diltiazem on steady state concentrations of digoxin was evaluated in eleven patients with …

Abstract Between January 1981 and April 1984, excessive serum concentrations of digoxin
(5 ng/ml or higher) were recorded in 47 children, aged 2 days to 16 years. In 10 patients, the …

The effect of the shock state on myocardial digoxin uptake and plasma digoxin levels was
examined in unanesthetized dogs following hemorrhage. Five minutes after intravenous …

Tritiated (12α‐3H) digoxin (0· 05 mg/kg body weight) was administered intravenously to
conscious dogs with circulatory volume overload induced by previous creation of aorto …

The effect of digoxin on the contractility of the nonfailing heart was studied in anaesthetized
dogs receiving continuous infusion of digoxin 0.8 jig/kg/min. The contractility, described by …

The time course of the rise in serum digoxin concentration was followed in 18 patients
treated with digoxin as quinidine treatment was started with a loading dose. The mean …

A study designed to investigate the relationship between the pharmacokinetics of digoxin
and a measure of its pharmacological effect has been conducted. Serum digoxin …

Despite warnings about improper use of blood concentrations of drugs"-'physicians persist
in regarding them as a diagnostic guide to drug effects on the body (ie, pharmacodynamics) …

Seven healthy volunteers received a single 1.0‐mg dose of intravenous digoxin in a drug‐
free control trial and again during concurrent therapy with therapeutic doses of quinidine …