Cell-wall sorted proteins of the Staphylococcus aureus iron-regulated surface determinant
system bind human hemoproteins, remove the heme molecule, and transport heme through …

Pathogenic Gram-positive bacteria encounter many obstacles in route to successful invasion
and subversion of a mammalian host. As such, bacterial species have evolved clever ways …

The pathogenesis of human infections caused by the gram-positive microbe Staphylococcus
aureus has been previously shown to be reliant on the acquisition of iron from host …

Staphylococcus aureus is a human pathogen that represents a tremendous threat to global
public health. An important aspect of S. aureus pathogenicity is the ability to acquire iron …

Iron acquisition is a vital process for most pathogenic bacteria, as iron is a limiting nutrient
during infection. Staphylococcus aureus, an increasingly important pathogen, acquires iron …

The iron-regulated surface determinants (Isd) of Staphylococcus aureus, including surface
proteins IsdA, IsdB, IsdC, and IsdH and ATP-binding cassette transporter IsdDEF, constitute …

The unique redox potential of iron makes it an ideal cofactor in diverse biochemical
reactions. Iron is therefore vital for the growth and proliferation of nearly all organisms …

The bacterial pathogen Staphylococcus aureus is responsible for a significant amount of
human morbidity and mortality, and the ability of S. aureus to cause disease is absolutely …

The use of iron as an enzymatic cofactor is pervasive in biological systems. Consequently
most living organisms, including pathogenic bacteria, require iron to survive and replicate …

Staphylococcus aureus scavenges heme-iron from host hemoproteins using iron-regulated
surface determinant (Isd) proteins. IsdC is the central conduit through which heme is passed …