Neural tube closure is a dynamic morphogenic event in early embryonic development.
Perturbations of this process through either environmental or genetic factors induce the …

Defects in closure of embryonic tissues such as the neural tube, body wall, face and eye
lead to severe birth defects. Cell adhesion is hypothesized to contribute to closure of the …

It is fundamentally important that signaling gradients provide positional information to govern
morphogenesis of multicellular organisms. Morphogen gradients can generate different cell …

Vangl2 forms part of the planar cell polarity signalling pathway and is the gene defective in
the Looptail (Lp) mouse mutant. Two previously described alleles, Lp and Lpm1Jus …

Spina bifida (SB) is a complex disorder of failed neural tube closure during the first month of
human gestation, with a suspected etiology involving multiple gene and environmental …

Gbx2 encodes a DNA-binding transcription factor that plays pivotal roles during
embryogenesis. Gain-and loss-of-function studies in several vertebrate species have …

Gbx2 is a homeobox gene that plays a crucial role in positioning the mid/hindbrain organizer
(isthmus), which regulates midbrain and cerebellar development primarily through the …

The highly-conserved Grainyhead-like (Grhl) transcription factors are critical regulators of
embryogenesis that regulate cellular survival, proliferation, migration and epithelial integrity …

Spina bifida is one of the most common neural tube defects (NTDs) with a complex etiology.
Variants in planar cell polarity (PCP) genes have been associated with NTDs including …

The Gbx class of homeobox genes encodes DNA binding transcription factors involved in
regulation of embryonic central nervous system (CNS) development. Gbx1 is dynamically …