The receptor tyrosine kinase Ror2 is a major Wnt receptor that activates β-catenin-
independent signaling and plays a conserved role in the regulation of convergent extension …

Neural tube defects (NTD) are clinically important congenital malformations whose
molecular mechanisms are poorly understood. The loop-tail (Lp) mutant mouse provides a …

Sonic hedgehog (Shh) signaling is the morphogen signaling that regulates embryonic
craniofacial and neural tube development. G protein-coupled receptor 161 (Gpr161) is a …

Sonic hedgehog (Shh) signaling regulates multiple morphogenetic processes during
embryonic neurogenesis and craniofacial skeletal development. Gpr161 is a known …

Abstract Mutations in IRF6, TFAP2A and GRHL3 cause orofacial clefting syndromes in
humans. However, Tfap2a and Grhl3 are also required for neurulation in mice. Here, we …

The mental retardation-associated protein, srGAP3 is highly expressed in neurogenic sites.
It is thought to regulate the key aspects of neuronal development and functions. Little is …

Loss‐of‐function mutations of Glypican 3 (Gpc3) cause the Simpson–Golabi–Behmel
overgrowth syndrome (SGBS), and developmental overgrowth is observed in Gpc3‐null …

Background Neural tube defects (NTDs) are among the most common congenital defects
affecting approximately 1 in 1000 live births in North America. Their etiology is complex …

Disruption of apical–basal polarity is implicated in developmental disorders and cancer;
however, the mechanisms connecting cell polarity proteins with intracellular signaling …

Danforth's short tail (Sd) mice provide an excellent model for investigating the underlying
etiology of human caudal birth defects, which affect 1 in 10 000 live births. Sd animals …