PURPOSE: The hedgehog (Hh) signaling pathway is activated in some adult cancers. On
the other hand, the Hh signaling pathway plays an important role in the development of the …

The c‐Met receptor and its ligand scatter factor/hepatocyte growth factor (SF/HGF) are
strongly overexpressed in malignant gliomas. Signaling through c‐Met as well as exposure …

Most neuroblastomas with N-myc amplification, a sign of extremely poor prognosis, are
extensively invasive to surrounding tissues. Therefore, we investigated the relationship …

Background Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of
mesothelial origin that shows a limited response to conventional chemotherapy and …

Background Lactate accumulation leads to an acidic tumor microenvironment (TME), in turn
promoting colorectal cancer (CRC) progression. Tumor-associated macrophages (TAMs) …

Neuroblastomas that overexpress N-Myc due to amplification of the MYCN oncogene are
aggressive tumors that become very resistant to treatment by chemotherapy and irradiation …

Background/Aim: We studied the effects of CO2 concentration changes on the invasive
ability of colon cancer cells. Materials and Methods: Colon cancer cell lines and human …

OBJECTIVE: To observe the effects of intravenous injection of HMGB1 inhibitor sodium
butyrate on changes in apoptosis of PMN during LPS-induced acute lung injury in rats and …

Glucose deprivation, hypoxia and acidosis are characteristic features of the central core of
most solid tumours. Myofibroblasts are stromal cells present in many such solid tumours …

Neuroblastoma is the most frequent extracranial solid tumour of childhood. Despite multiple
clinical efforts, clinical outcome has remained poor. Neuroblastoma is considered to be …