Peritoneal carcinomatosis of colorectal cancer is common and associated with poor
prognosis, which poses a serious challenge and satisfactory treatments are urgently …

Hypoxia within solid tumors is a major determinant of outcome after anticancer therapy.
Analysis of gene expression changes during hypoxia indicated that unfolded protein …

Background The purposes of this study were to explore the effects of high mobility group
protein box 1 (HMGB1) gene on the growth, proliferation, apoptosis, invasion, and …

Tumor hypoxia has been attributed to play a crucial role in tumorigenesis and therapeutic
resistance. Recently, it has been suggested that hypoxia leads to and maintains the …

Laparoscopic surgery for malignant disease is highly controversial mainly due to the large
number of abdominal wall metastases being reported. Previous experimental studies have …

Purpose MYCN oncogene amplification is an independent predictor of poor prognosis in
neuroblastoma. CX-5461 is a small molecular inhibitor that prevents initiation of ribosomal …

The tumor microenvironment has previously been reported to be hypercapnic (as high as~
84 mmHg), although its effect on tumor cell behaviors is unknown. In this study, high CO 2 …

In human neuroblastoma, amplification of the MYCN gene predicts poor prognosis and
resistance to therapy. Because hypoxia contributes to aggressive tumor phenotypes …

Purpose: Medulloblastoma in children can be categorized into at least four molecular
subgroups, offering the potential for targeted therapeutic approaches to reduce treatment …

Hypoxia commonly occurs in solid tumors of the central nervous system (CNS) and often
interferes with therapies designed to stop their growth. We found that pediatric high-grade …