Background Aberrant activation of the hedgehog (Hh) signaling pathway is implicated
widely in both pediatric and adult malignancies. Inactivation of the Hh regulator PTCH is …

OBJECTIVES: Hypoxia enhances malignant progression by promoting the development of
metastases and increasing invasiveness. One key regulator that controls growth, invasion …

Abstract Background/Aim: High mobility group box 1 protein (HMGB1) is functionally
dynamic and pleiotropic molecule, it has the potential to promote both cell survival and …

Altered expression of carbonic anhydrase (CA) II is associated with human carcinogenesis.
We analysed CA II protein expression in 89 patients with pseudomyxoma peritonei (PMP) …

Background: Pleural effusion is one of the complications of human non-small cell lung
cancer (NSCLC). High mobility group box-1 protein (HMGB1) correlates highly with invasion …

Purpose To explore the regulatory effect of HMGB1 upon hypoxia-induced mitochondrial
biogenesis in pancreatic cancer PANC1/CFPAC1 cells. Methods After a down-regulation of …

OBJECTIVE: To investigate the function of HMGB2 in renal tumor ACHN cells in vitro and in
vivo and to study the underlying molecular mechanisms. PATIENTS AND METHODS …

We have recently found that cells derived from human neuroblastoma, a sympathetic
nervous system (SNS) tumor, dedifferentiate and acquire a neural crest-like phenotype …

Osteosarcoma is the most common primary solid malignant bone tumor. Despite substantial
improvements in surgery and chemotherapy, metastasis remains a major cause of fatal …

High-mobility group box 1 (HMGB1) was found to be over-expressed in many kinds of
human cancer, which binds with several receptors and activates RAGE-Ras-MAPK, Toll-like …