The precise modulation of regional cerebral blood flow during neural activation is important
for matching local energetic demand and supply and clearing brain metabolites. Here we …

The neurovascular mechanisms underpinning the local regulation of cerebral blood flow
(CBF) and oxygen transport remain elusive. In this study we have combined novel in vivo …

The spatiotemporal evolution of cerebral microcirculatory adjustments to functional brain
stimulation is the fundamental determinant of the functional specificity of hemodynamically …

Capillary perfusion in the brain is characterized by an essentially continuous flow of
erythrocytes and plasma in almost all capillaries. Rapid fluctuations and spatial …

The cortical angioarchitecture is a key factor in controlling cerebral blood flow and oxygen
metabolism. Difficulties in imaging the complex microanatomy of the cortex have so far …

Cortical blood flow at the level of individual capillaries and the coupling of neuronal activity
to flow in capillaries are fundamental aspects of homeostasis in the normal and the diseased …

Rises in local neural activity trigger local increases of cerebral blood flow, which is essential
to match local energy demands. However, the specific location of microvascular flow control …

Elaborate modeling study suggests an important role of capillary transit time heterogeneity
(CTTH) reduction in brain oxygenation during functional hyperemia. Here, we use optical …

Local blood flow in the brain is tightly coupled to metabolic demands, a phenomenon termed
functional hyperemia. Both capillaries and arterioles contribute to the hyperemic response to …

Pial arterioles actively change diameter to regulate blood flow to the cortex. However, it is
unclear whether arteriole reactivity and its homeostatic role of conserving red blood cell …