Imaging the construction of capillary networks in the neonatal mouse brain

V Coelho-Santos, AA Berthiaume… - Proceedings of the …, 2021 - National Acad Sciences
Capillary networks are essential for distribution of blood flow through the brain, and
numerous other homeostatic functions, including neurovascular signal conduction and …

Dynamic In Vivo Measurement of Erythrocyte Velocity and Flow in Capillaries and of Microvessel Diameter in the Rat Brain by Confocal Laser Microscopy

J Seylaz, R Charbonné, K Nanri… - Journal of Cerebral …, 1999 - journals.sagepub.com
A new method for studying brain microcirculation is described, Both fluorescently labeled
erythrocytes and plasma were visualized on-line through a closed cranial window in …

Vascular Tone and Neurovascular Coupling: Considerations Toward an Improved In Vitro Model

JA Filosa - Frontiers in neuroenergetics, 2010 - frontiersin.org
Neurovascular research has made significant strides toward understanding how the brain
neurovascular unit accomplishes rapid and spatial increases in blood flow following …

The contribution of astrocytes to the regulation of cerebral blood flow

C Howarth - Frontiers in neuroscience, 2014 - frontiersin.org
In order to maintain normal brain function, it is critical that cerebral blood flow (CBF) is
matched to neuronal metabolic needs. Accordingly, blood flow is increased to areas where …

Advanced in vitro approach to study neurovascular coupling mechanisms in the brain microcirculation

KJ Kim, JA Filosa - The Journal of physiology, 2012 - Wiley Online Library
Key points• We show that parenchymal arterioles of less than 30 μm in diameter can be
successfully cannulated and perfused in cortical and hypothalamic brain slices.• Increased …

Macro-to-micro cortical vascular imaging underlies regional differences in ischemic brain

S Dziennis, J Qin, L Shi, RK Wang - Scientific reports, 2015 - nature.com
The ability to non-invasively monitor and quantify hemodynamic responses down to the
capillary level is important for improved diagnosis, treatment and management of …

Label-free in vivo optical imaging of functional microcirculations within meninges and cortex in mice

Y Jia, RK Wang - Journal of neuroscience methods, 2010 - Elsevier
Abnormal microcirculation within meninges is common in many neurological diseases.
There is a need for an imaging method that is capable of monitoring dynamic meningeal …

Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping

D Malonek, A Grinvald - Science, 1996 - science.org
Modern neuroimaging techniques use signals originating from microcirculation to map brain
function. In this study, activity-dependent changes in oxyhemoglobin, deoxyhemoglobin, and …

Glymphatic influx and clearance are accelerated by neurovascular coupling

S Holstein-Rønsbo, Y Gan, MJ Giannetto… - Nature …, 2023 - nature.com
Functional hyperemia, also known as neurovascular coupling, is a phenomenon that occurs
when neural activity increases local cerebral blood flow. Because all biological activity …

Imaging system for three-dimensional mapping of cerebrocortical capillary networks in vivo

AG Hudetz, AS Greene, G Fehér, DE Knuese… - Microvascular …, 1993 - Elsevier
A personal computer-based image analysis system was developed for the three-
dimensional mapping of cerebrocortical capillary networks from intravital video recordings …