The NLRP3 inflammasome, as an important component of the innate immune system, plays
vital roles in various metabolic disorders. It has been reported that the NLRP3 …

NLRP3 is a cytosolic pattern recognition receptor that is activated in response to a broad
range of pathogen-derived and endogenous agents. NLRP3 assembles an inflammasome …

Despite the fact that deregulated NLRP3 inflammasome activation contributes to the
pathogenesis of chronic inflammatory or metabolic disorders, the underlying mechanism by …

The NLRP3 inflammasome is activated by a variety of external or host-derived stimuli and its
activation initiates an inflammatory response through caspase-1 activation, resulting in …

Recognition of the translocation of NLRP3 to various organelles has provided new insights
for understanding how the NLRP3 inflammasome is activated by different stimuli …

Inflammasomes are multimeric protein complexes that induce the cleavage and release of
bioactive IL-1β and cause a lytic form of cell death, termed pyroptosis. Due to its diverse …

As an intracellular polyprotein complex, the NLRP3 inflammasome is activated by NLRP3
perceiving pathogen-related molecular patterns, damage-related molecular patterns …

The NACHT, leucine-rich repeat, and pyrin domains-containing protein 3 (collectively known
as NLRP3) inflammasome activation plays a critical role in innate immune and pathogenic …

Background The NLRP3 inflammasome is a sensor of specific pathogen, host and
environmental danger molecules. Upon activation NLRP3 recruits caspase-1, which cleaves …

Inflammasomes represent protective weapons against pathogens and cellular damage,
although their uncontrolled activation drives the progression of inflammatory, metabolic, and …