Reversible phosphorylation and dephosphorylation of key proteins on tyrosine residues are
important parts of intracellular signaling triggered by hormones and other agents. Recent …

Protein-tyrosine phosphatases (PTPs) are considered important therapeutic targets because
of their pivotal role as regulators of signal transduction and thus their implication in several …

Protein tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signaling in part by
dephosphorylating key tyrosine residues within the regulatory domain of the β-subunit of the …

Protein tyrosine phosphatases (PTPs), a large family of signaling enzymes, play essential
roles in intracellular signal transduction by regulating the cellular level of tyrosine …

The protein tyrosine phosphatases (PTPases or PTPs) play an important role in controlling
the status of tyrosine phosphorylation and the regulation of cellular function. The ability to …

Protein tyrosine phosphatases (PTPs) constitute a diverse family of enzymes that, together
with protein tyrosine kinases, control the level of intracellular tyrosine phosphorylation, thus …

Several protein-tyrosine phosphatases (PTPs) have been proposed to act as negative
regulators of insulin signaling. Recent studies have shown increased insulin sensitivity and …

Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that downregulates the insulin
receptor. Inhibition of PTP1B is expected to improve insulin action, and the design of small …

Protein tyrosine phosphatases (PTPs) superfamily catalyzes tyrosine de‐phosphorylation
which affects a myriad of cellular processes. Imbalance in signal pathways mediated by …

Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous
cellular processes, and several PTPs have been validated as therapeutic targets for human …