In decades, the efficiency of glioma therapy is far from satisfaction due to the inability of most
therapeutics to accumulate at the glioblastoma (GBM) site. Therefore, it is urgent to develop …

Delivering therapeutics to a brain tumor is a challenge because of the tightly regulated blood
brain barrier (BBB) as well as the dense and sticky extracellular matrix (ECM) composed …

Traditional glioma chemotherapy with those second‐line drugs such as anthracyclines
usually failed because they are inaccessible to blood–brain barrier (BBB) in tumor. In our …

Glioblastoma Multiforme (GBM) is a highly prevalent and deadly brain malignancy
characterized by poor prognosis and restricted disease management potential. Despite the …

In the present investigation, temozolomide (TMZ) loaded chondroitin sulfate conjugated
albumin nanoparticles (CS-TNPs) were fabricated by desolvation method were chondroitin …

The aims of this study were to develop and characterize curcumin (CCM) and docetaxel
(DTX) co-loaded poly lactide-co-glycolide (PLGA) nanoparticles (NPs) to overcome blood …

Gliomas are the most common malignant brain tumor, but treatment is limited by the blood–
brain barrier (BBB), especially for chemotherapeutic drugs. Although some chemotherapy …

Hybrid nanoparticles consisting of lipids and the biodegradable polymer, poly (D, L-lactide-
co-glycolide)(PLGA), were developed for the targeted delivery of the anticancer drug …

Madecassoside (MAD), an ursane type pentacyclic triterpenoid saponin, isolated from
Centella asiatica (CA) possesses various pharmacological activities. The aim of this study …

Glioblastoma multiforme (GBM), a prevalent brain cancer with high mortality, is resistant to
the conventional single-agent chemotherapy. In this study, we employed a combination …