Acute selective serotonin reuptake inhibitors increase conditioned fear expression: blockade with a 5-HT2C receptor antagonist

NS Burghardt, DEA Bush, BS McEwen, JE LeDoux - Biological psychiatry, 2007 - Elsevier
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) effectively treat various
anxiety disorders, although symptoms of anxiety are often exacerbated during early stages …

The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptine

NS Burghardt, GM Sullivan, BS McEwen, JM Gorman… - Biological …, 2004 - Elsevier
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are efficacious in the
treatment of a variety of fear or anxiety disorders. Although they inhibit the reuptake of …

SSRIs and conditioned fear

T Inoue, Y Kitaichi, T Koyama - Progress in Neuro-Psychopharmacology …, 2011 - Elsevier
Among drugs that act on serotonergic neurotransmission, selective serotonin (5-HT)
reuptake inhibitors (SSRIs) are now the gold standard for the treatment of anxiety disorders …

Chronic antidepressant treatment impairs the acquisition of fear extinction

NS Burghardt, T Sigurdsson, JM Gorman… - Biological …, 2013 - Elsevier
BACKGROUND: Like fear conditioning, the acquisition phase of extinction involves new
learning that is mediated by the amygdala. During extinction training, the conditioned …

Acute and chronic effects of selective serotonin reuptake inhibitor treatment on fear conditioning: implications for underlying fear circuits

NS Burghardt, EP Bauer - Neuroscience, 2013 - Elsevier
Selective serotonin reuptake inhibitors (SSRIs) are widely used for the treatment of a
spectrum of anxiety disorders, yet paradoxically they may increase symptoms of anxiety …

A role for the extended amygdala in the fear-enhancing effects of acute selective serotonin reuptake inhibitor treatment

S Ravinder, NS Burghardt, R Brodsky, EP Bauer… - Translational …, 2013 - nature.com
Selective serotonin reuptake inhibitors (SSRIs) are reported to exacerbate symptoms of
anxiety when treatment is initiated. These clinical findings have been extended to animal …

The effect of SSRIs on fear learning: a systematic review and meta-analysis

EJ Heesbeen, EY Bijlsma, PM Verdouw… - …, 2023 - Springer
Rationale Selective serotonin reuptake inhibitors (SSRIs) are considered first-line
medication for anxiety-like disorders such as panic disorder, generalized anxiety disorder …

Two-week treatment with the selective serotonin reuptake inhibitor citalopram reduces contextual anxiety but not cued fear in healthy volunteers: a fear-potentiated …

C Grillon, C Chavis, MF Covington… - …, 2009 - nature.com
Chronic treatment with selective serotonin reuptake inhibitors (SSRIs) alleviates both anxiety
symptoms and associated physiologic disturbances in anxious patients. However, limited …

Selective serotonin reuptake inhibitor reduces conditioned fear through its effect in the amygdala

T Inoue, XB Li, T Abekawa, Y Kitaichi, T Izumi… - European journal of …, 2004 - Elsevier
Selective serotonin reuptake inhibitors are first-line treatment for most anxiety disorders, but
their mechanism of anxiolytic action has not been clarified. Selective serotonin reuptake …

Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not …

G Bagdy, M Graf, ZE Anheuer… - International Journal …, 2001 - academic.oup.com
The possible role of 5-HT1A and 5-HT2C receptors in the anxiety induced by fear, acute
treatment with SSRI antidepressants or the 5-HT receptor agonist m-CPP were tested in the …