While aerobic glycolysis, or the Warburg effect, has for a long time been considered a
hallmark of tumor metabolism, recent studies have revealed a far more complex picture …

Autophagy, or self-eating, is the most extensively studied lysosomal degradation pathway for
the recycling of obsolete or damaged cytoplasmic materials, including proteins and …

Glutamine metabolism is crucial for cancer cell growth via the generation of intermediate
molecules in the tricarboxylic acid (TCA) cycle, antioxidants and ammonia. The goal of the …

Metabolic synergy or metabolic coupling between glycolytic stromal cells (Warburg effect)
and oxidative cancer cells occurs in human breast cancers and promotes tumor growth. The …

Autophagy is a critical cellular process that generally protects cells and organisms from
harsh environment, including limitations in adenosine triphosphate (ATP) availability or a …

Most cancer cells predominantly produce energy by glycolysis, even in the presence of
adequate oxygen. Therefore, inhibition of glycolysis is a promising cancer treatment target …

Simple Summary The characteristic metabolic hallmark of cancer cells is the massive
catabolism of glucose by glycolysis, even under aerobic conditions—the so-called Warburg …

Normal healthy cells generate energy-carrying molecule, Adenosine Triphosphate (ATP), by
oxidative breakdown of pyruvate within the mitochondria. Conversely, cancer cells avoid this …

Metabolic reprogramming in tumours is now recognized as a hallmark of cancer,
participating both in tumour growth and cancer progression. Cancer cells develop global …

Elevated glycolysis and impaired oxidative phosphorylation (Warburg effect) is one of the
classical features of cancer. Cancer cells, in order to support their growth and proliferation …