The Warburg effect refers to a metabolic alteration seen in cancer cells, distinguished by an
increased absorption and use of glucose. The sustained stimulation of aerobic glycolysis in …

One important feature of tumour development is the regulatory role of metabolic plasticity in
maintaining the balance of mitochondrial oxidative phosphorylation and glycolysis in cancer …

Since Otto Warburg first proposed that cancer cells have defective mitochondrial metabolism
with enhanced aerobic glycolysis almost 100 years ago, uncovering the unique metabolic …

abstract Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …

Cancer is a complex disease marked by uncontrolled cell growth and invasion. These
processes are driven by the accumulation of genetic and epigenetic alterations that promote …

Osteosarcoma is a rare primary malignant tumor of the bone. It is a childhood cancer and
has a peak incidence in the second decade of life. Unfortunately, osteosarcoma has a poor …

The Transforming growth factor-β1 (TGF-β1) in the tumor microenvironment (TME) is the
major cytokine that acts as a mediator of tumor-stroma crosstalk, which in fact has a dual role …

Cancer cells reprogram their energy metabolism to suit their growth and proliferation needs.
Cancer cells upregulate glycolysis even in the presence of oxygen, a phenomenon termed …

The selective elimination of mitochondria via mitophagy is important in regulating multiple
cellular processes ranging from cell growth, quiescence, metabolic alterations, proliferation …

A defining hallmark of tumor phenotypes is uncontrolled cell proliferation, while fermentative
glycolysis has long been considered as one of the major metabolic pathways that allows …