Cancer stem cells (CSCs) play a key role in regulating tumorigenesis, progression, as well
as recurrence, and possess typical metabolic characteristics. Autophagy is a catabolic …

When oxygen is present, normal cells use mitochondria to oxidize glucose, but in the
absence of oxygen, glucose is converted into lactate. About 90 years ago, the renowned …

Reprogramming energy metabolism from oxidative phosphorylation to aerobic glycolysis, a
common feature of human cancer, is associated with a relative acidic tumor …

Energetic pathways combine in the heart of metabolism. These essential routes supply
energy for biochemical processes through glycolysis and oxidative phosphorylation …

Background Mitophagy refers to the selective self‐elimination of mitochondria under
damaged or certain developmental conditions. As an important regulatory mechanism to …

Otto Warburg described his seminal observation that cancer cells negotiated a switch
towards anaerobic respiration from oxidative phosphorylation in return for sustained growth …

Modulation of autophagy as an anticancer strategy has been widely studied and evaluated
in several cell models. However, little attention has been paid to the metabolic changes that …

Background As an important regulatory mechanism to remove damaged mitochondria and
maintain the balance between internal and external cells, mitochondrial autophagy plays a …

Emerging knowledge supports the notion that metabolic reprogramming facilitates the
progression of many cancers and in some it could be initiated by mutations in genes related …

Background: Human cells may switch metabolism from aerobic to anaerobic or vice versa
depending on cellular conditions. The use of anaerobic cellular respiration is especially …