Obesity is a significant global public health concern that is associated with an elevated risk
of comorbidities as well as severe postoperative and nosocomial infections. The treatment of …

As the prevalence of obesity continues to rise significantly worldwide, an increasing number
of overweight patients are expected to present to hospital with various pathological …

Physiologic alterations seen in obesity commonly impact the pharmacokinetics (PK) and
pharmacodynamics (PD) of antibiotics and may result in suboptimal dosing in this …

The increased prevalence of obesity presents challenges for clinicians aiming to provide
optimised antimicrobial dosing in the intensive care unit. Obesity is likely to exacerbate the …

The prevalence of obesity has increased considerably in the last few decades.
Pathophysiological changes in obese patients lead to pharmacokinetic (PK) and …

What is known and objective Obesity is a significant burden on the healthcare system in the
U nited S tates, and determining the appropriate antimicrobial dosing regimen in morbidly …

Résumé Comme la prévalence de l'obésité augmente dans le monde, le clinicien sera de
plus en plus fréquemment confronté à des patients obèses en réanimation. Il est …

Highlights•A singular approach to antimicrobial dose selection in obese patients is not
feasible.•Total body weight based dosing risks over exposure and toxicity in obese …

The impact of adjusted treatment on clinical outcomes in patients with severe obesity is
unclear. This study included adults with severe obesity admitted for bloodstream infections …

Five hundred million adults meet the current definition of obesity worldwide. This high global
prevalence of obesity offers unique challenges to the selection of the optimal antimicrobial …