Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN)
is the most important mediating mechanism. This mechanism involves direct action of …

The disabling human syndrome of “neuropathic pain” is an intractable complication of
peripheral nerve injury or degeneration. A complex interaction between injured peripheral …

A large body of evidence indicates that nitric oxide (NO) plays an important role in the
processing of persistent inflammatory and neuropathic pain in the spinal cord. Several …

Pharmacologic, electrophysiologic, and immunohistochemical studies have suggested a
role of nitric oxide (NO) in nociception processing. Recent studies have indicated that NO …

New Findings What is the central question of this study? Can modulation of inducible NO
synthase reduce pain behaviour and pro‐inflammatory cytokine signalling in a rat model of …

The aim of this study is to investigate the involvement of nitric oxide synthesized by the
inducible (NOS2) or neuronal (NOS1) nitric oxide synthases in the local antinociceptive …

Tissue injury can initiate bidirectional signaling between neurons, glia, and immune cells
that creates and amplifies pain. While the ability for neurotransmitters, neuropeptides, and …

Emerging lines of evidence indicate that production of reactive oxygen species (ROS) at
distinct sites of the nociceptive system contributes to the processing of neuropathic pain …

Nitric oxide (NO) is a versatile messenger molecule first associated with endothelial relaxing
effects. In the central nervous system (CNS), NO synthesis is primarily triggered by activation …

Two reactive oxygen species (ROS), nitric oxide (NO•) and superoxide (• O 2−), contribute to
persistent pain. Using three different animal models where ROS mediate pain, this study …