Abstract Development of a new drug for the treatment of lung disease is a complex and time
consuming process involving numerous disciplines of basic and applied sciences. During …

Introduction The deposition of inhaled medications is the first step in the pulmonary
pharmacokinetic process to produce a therapeutic response. Not only lung dose, but more …

Pulmonary delivery for both locally and systemically acting drugs provides not only a
potentially convenient route but also a challenging area to pharmaceutical research. Drug …

The success of inhalation therapy is not only dependent upon the pharmacology of the
drugs being inhaled but also upon the site and extent of deposition in the respiratory tract …

Introduction: Pulmonary drug delivery is a complex field of research combining physics
which drive aerosol transport and deposition and biology which underpins efficacy and …

In order to answer the question “what research remains to be done?” we review the current
state of the art in pharmaceutical aerosol deposition modeling and explore possible in vivo …

Ideally, inhaled therapy is driven by the needs of specific disease management. Lung
biology interfaces with inhaler performance to allow optimal delivery of therapeutic agent for …

Mathematical and in vitro models, that incorporate particle diameter, normal breathing
frequencies and tidal volumes, have been used to predict the deposition fraction of …

Background: While it is generally accepted that inertial impaction will lead to particle loss as
aerosol is being carried into the pulmonary airways, most predictive aerosol deposition …

The pulmonary route has been used with success for the treatment of both lung (asthma)
and systemic diseases (diabetes). The fate of an inhaled drug (absorption and deposition) …