Epistasis and covariance: how gene interaction translates into genomic relationship
Key message Models based on additive marker effects and on epistatic interactions can be
translated into genomic relationship models. This equivalence allows to perform predictions …
translated into genomic relationship models. This equivalence allows to perform predictions …
Genome-Wide Association Studies with a Genomic Relationship Matrix: A Case Study with Wheat and Arabidopsis
Standard genome-wide association studies (GWAS) scan for relationships between each of
p molecular markers and a continuously distributed target trait. Typically, a marker-based …
p molecular markers and a continuously distributed target trait. Typically, a marker-based …
[HTML][HTML] On the approximation of interaction effect models by Hadamard powers of the additive genomic relationship
JWR Martini, FH Toledo, J Crossa - Theoretical population biology, 2020 - Elsevier
Whole genome epistasis models with interactions between different loci can be
approximated by genomic relationship models based on Hadamard powers of the additive …
approximated by genomic relationship models based on Hadamard powers of the additive …
[HTML][HTML] Locally epistatic models for genome-wide prediction and association by importance sampling
Background In statistical genetics, an important task involves building predictive models of
the genotype–phenotype relationship to attribute a proportion of the total phenotypic …
the genotype–phenotype relationship to attribute a proportion of the total phenotypic …
Bayesian Networks Illustrate Genomic and Residual Trait Connections in Maize (Zea mays L.)
Relationships among traits were investigated on the genomic and residual levels using
novel methodology. This included inference on these relationships via Bayesian networks …
novel methodology. This included inference on these relationships via Bayesian networks …
[HTML][HTML] Genotype–covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model
G Ni, J Van Der Werf, X Zhou, E Hyppönen… - Nature …, 2019 - nature.com
The genomics era has brought useful tools to dissect the genetic architecture of complex
traits. Here we propose a multivariate reaction norm model (MRNM) to tackle genotype …
traits. Here we propose a multivariate reaction norm model (MRNM) to tackle genotype …
Phantom epistasis in genomic selection: on the predictive ability of epistatic models
MF Schrauf, JWR Martini, H Simianer… - G3: Genes …, 2020 - academic.oup.com
Genomic selection uses whole-genome marker models to predict phenotypes or genetic
values for complex traits. Some of these models fit interaction terms between markers, and …
values for complex traits. Some of these models fit interaction terms between markers, and …
Optimising the identification of causal variants across varying genetic architectures in crops
Association studies use statistical links between genetic markers and the phenotype
variation across many individuals to identify genes controlling variation in the target …
variation across many individuals to identify genes controlling variation in the target …
Haplotype-based genome-wide prediction models exploit local epistatic interactions among markers
Genome-wide prediction approaches represent versatile tools for the analysis and
prediction of complex traits. Mostly they rely on marker-based information, but scenarios …
prediction of complex traits. Mostly they rely on marker-based information, but scenarios …
Efficient algorithms for calculating epistatic genomic relationship matrices
The genomic relationship matrix plays a key role in the analysis of genetic diversity, genomic
prediction, and genome-wide association studies. The epistatic genomic relationship matrix …
prediction, and genome-wide association studies. The epistatic genomic relationship matrix …