The extracellular matrix (ECM) is extensively remodeled in tumor tissues. Overproduction of
collagens, pathological collagen crosslinking and alignment of fibers are major processes …

Colorectal cancer is the second most common cancer diagnosed in men and the third most
commonly occurring in women worldwide. Interactions between cells and the surrounding …

Extracellular matrix (ECM) is an essential and dynamic component of all tissues and directly
affects cellular behavior by providing both mechanical and biochemical signaling cues …

The extracellular matrix (ECM) from perilesional and colorectal carcinoma (CRC), but not
healthy colon, sustains proliferation and invasion of tumor cells. We investigated the …

Biological materials such as extracellular matrix scaffolds, cancer cells, and tissues are often
assumed to respond elastically for simplicity; the viscoelastic response is quite commonly …

Tumor progression in vitro has traditionally been studied in the context of two-dimensional
(2D) environments. However, it is now well accepted that 2D substrates are unnaturally rigid …

Alteration in the density and composition of extracellular matrix (ECM) occurs in tumors. The
alterations toward both stiffness and degradation are contributed to tumor growth and …

It is well established that collagen alignment in the breast tumor microenvironment provides
biophysical cues to drive disease progression. Numerous mechanistic studies have …

Increased stiffness in the extracellular matrix (ECM) contributes to tumor progression and
metastasis. Therefore, stromal modulating therapies and accompanying biomarkers are …

Deregulated dynamics of the extracellular matrix (ECM) are one of the hallmarks of cancer.
Studies on tumor mechanobiology are thus expected to provide an insight into the disease …