Opioid-based narcotics are a major component of pain management, but are problematic
due to negative side effects mediated by the central nervous system. Pain management can …

Leukotrienes (LTs) belong to a large family of lipid mediators, termed eicosanoids, which are
derived from arachidonic acids and released from the cell membrane by phospholipases …

We investigated the antinociceptive effect of a novel anti-inflammatory and analgesic d rug,
3-(difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfinyl) phenyl] pyrazole (FR140423) …

We tested the influence of magnesium, zinc and copper upon the montelukast (MK,
antagonist of cysteinyl leukotriene receptor type 1) effect in experimentally-induced …

Abstract Cuminic alcohol (4-isopropylbenzyl alcohol; 4-IPBA) is a monocyclic terpenoid
found in the analgesic medicinal plants Cuminum cyminum and Bunium persicum. The …

Gastric mucosal damage is a common disorder of the gastrointestinal system. Non-steroidal
anti-inflammatory drugs (NSAID) are known to be aggressive agents for gastric ulcer …

We previously reported that administration of (−)-linalool, the naturally occurring enantiomer
in essential oils, induced a significant reduction in carrageenin-induced oedema and in …

Background Rutin is a bioflavonoid found in fruits, vegetables and plants used in traditional
medicine to alleviate pain. However, rutin's scientific evidence for the modulation of pain and …

Crotalphine, a 14 amino acid peptide first isolated from the venom of the South American
rattlesnake Crotalus durissus terrificus, induces a peripheral long-lasting and opioid …

The involvement of nitric oxide (NO), cyclic GMP and ATP-sensitive K+ channels in the
antinociceptive effect of ketorolac was assessed using the formalin test in the rat. Local …