RNase protection assays were used in a comparative analysis of the quantities of mRNA for
five “calcium‐sensitive”(types I, III, V, VI, and VIII) adenylyl cyclases and one “calcium …

The localization of the nine identified isoforms of adenylyl cyclase in brain has been largely
based on determination of patterns of mRNA expression. A polyclonal antibody has now …

We studied the distribution of type II Ca 2+/calmodulin (CaM)-insensitive adenylyl cyclase
mRNA in the adult rat brain by in situ hybridization histochemistry. Although type II adenylyl …

Four monoclonal antibodies, raised against the 115‐kDa adenylyl cyclase from bovine brain
[Pfeuffer, E. et al.(1985) EMBO J. 4, 3675–3679] have been selected and designated BBC‐1 …

Only three isoforms of adenylyl cyclase (EC 4.6. 1.1) mRNAs (AC1,-2, and-5) are expressed
at high levels in rat brain. AC1 occurs predominantly in hippocampus and cerebellum, AC5 …

The activities of adenylyl cyclases (EC 4.6. 1.1, adenylate cyclase), which catalyze the
synthesis of cyclic AMP from ATP, are modulated by several cellular regulators, including …

Monoclonal antibodies against partially purified adenylyl cyclase from bovine brain cortex
were raised in mice. Three types of antibody were obtained. Type I was specific for the …

Biochemical, immunological, and molecular cloning studies have suggested the existence of
multiple forms of adenylyl cyclase (EC 4.6. 1.1). An adenylyl cyclase cDNA clone (type II) …

Hydrophobic chromatography of detergent‐solubilized rat brain adenylate cyclase on
dodecyl‐Sepharose produced a species that was soluble in the absence of detergent and …

We characterized a human cDNA clone which encodes a novel adenylyl cyclase. Data from
Southern and Northern blot analysis, and analysis of sequence similarity with a recently …