CD4 T‐cell function is crucial for the eradication of HCV, and insufficient function is observed
in chronic carriers. The monitoring of T‐cell responses is complicated by the scarcity of …

BACKGROUND & AIMS: Virus-specific CD4+ T cells play a major role in hepatitis C virus
(HCV) infection. Viral clearance is associated with vigorous and multispecific CD4+ T cell …

Background. Chronic hepatitis C virus (HCV) infection is characterized by reduced numbers
of functional HCV-specific T cells. In addition, chronically HCV-infected individuals have …

Costimulatory signals via B7/CD28 family molecules (signal 2) are critical for effective
adaptive CD8+ T cell immune responses. In addition to costimulatory signals, B7/CD28 …

Background: Clearance of hepatitis C virus (HCV) is attributed to host cellular immune
responses, in which T helper cells play a critical role. The purpose of the present paper was …

ABSTRACT CD8 T cells play a major role in antiviral immune responses. Their importance
for progression to chronic hepatitis C and response to treatment are still unclear. To address …

In the present study, high levels of CD30s, a glycoprotein preferentially expressed and
released by T lymphocytes producing Th2-type cytokines, were seen in the sera of patients …

Hepatitis C virus (HCV) causes chronic infection accompanied by a high risk of liver failure
and hepatocellular carcinoma. CD8+ T cell responses are important in the control of viremia …

Chronic hepatitis C is characterized by a weak or absent hepatitis C virus (HCV)-specific
CD4+ T-cell response in terms of antigen-specific proliferation or interferon gamma (IFN-γ) …

We comprehensively studied the cellular immune response during acute human hepatitis C
virus (HCV) infection by monthly prospective sampling of persons at high risk of infection. In …