The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT)
protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we …

Cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11; also known as
xCT) plays a key role in antioxidant defense by mediating cystine uptake, promoting …

The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …

Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and
bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently …

Amino acid transporters mediate substrates across cellular membranes and their fine-tuned
regulations are critical to cellular metabolism, growth, and death. As the functional …

SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival.
Here we show that this comes at a significant cost for cancer cells with high levels of …

SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange
for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione …

The cystine transporter solute carrier family 7 member 11 (SLC7A11)(also known as xCT)
promotes glutathione synthesis and counters oxidative stress–induced cell death, including …

System xc− is a sodium-independent electroneutral transporter, comprising a catalytic
subunit xCT (SLC7A11), which is involved in importing cystine. Certain cancers such as …

The solute carrier family 7 member 11 (SLC7A11), an amino acid transporter protein is
frequently overexpressed in human malignancies. The expression and activity of SLC7A11 …