[HTML][HTML] Therapeutic strategies for overcoming immunotherapy resistance mediated by immunosuppressive factors of the glioblastoma microenvironment

T Miyazaki, E Ishikawa, N Sugii, M Matsuda - Cancers, 2020 - mdpi.com
Various mechanisms of treatment resistance have been reported for glioblastoma (GBM)
and other tumors. Resistance to immunotherapy in GBM patients may be caused by …

[HTML][HTML] Systemic inflammatory indicators as prognosticators in glioblastoma patients: a comprehensive meta-analysis

C Yang, HB Wen, YH Zhao, WH Huang… - Frontiers in …, 2020 - frontiersin.org
Background: Inflammation plays an important role in tumorigenesis. Previous studies have
reported the prognostic value of several peripheral inflammatory markers in glioma patients …

Mechanisms of immunomodulation in human glioblastoma

T Avril, E Vauleon, S Tanguy-Royer, J Mosser… - …, 2011 - Taylor & Francis
Glioblastoma multiforme (GBM), WHO grade IV astrocytoma, is the most dramatic primary
brain cancer with a very poor prognosis due to inevitable disease recurrence. Less than …

[HTML][HTML] Challenges and opportunities for immunotherapeutic intervention against myeloid immunosuppression in glioblastoma

MA Exley, S Garcia, A Zellander, J Zilberberg… - Journal of Clinical …, 2022 - mdpi.com
Glioblastoma multiforme (GBM), the most common and deadly brain cancer, exemplifies the
paradigm that cancers grow with help from an immunosuppressive tumor microenvironment …

Immune landscape of isocitrate dehydrogenase stratified human gliomas

P Gupta, M Dang, S Oberai, M Peshoff, N Milam… - BioRxiv, 2022 - biorxiv.org
The brain tumor immune microenvironment (TIME) continuously evolves during glioma
progression, but only a limited view of a highly complex glioma associated immune …

[HTML][HTML] The role of myeloid cells in GBM immunosuppression

YJ Lin, CYJ Wu, JY Wu, M Lim - Frontiers in immunology, 2022 - frontiersin.org
Gliomas are intrinsic brain tumors that originate from glial cells. Glioblastoma (GBM) is the
most aggressive glioma type and resistant to immunotherapy, mainly due to its unique …

[HTML][HTML] Effect of radiochemotherapy on peripheral immune response in glioblastoma

L Hampe, S Daumoine, E Limagne, N Roussot… - Cancer Immunology …, 2024 - Springer
Background Glioblastoma (GBM) is a primary brain tumor with a dismal prognosis, often
resistant to immunotherapy and associated with immune suppression. This study aimed to …

[HTML][HTML] Differential microglia and macrophage profiles in human IDH-mutant and-wild type glioblastoma

CC Poon, PMK Gordon, K Liu, R Yang, S Sarkar… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Microglia and macrophages are the largest component of the inflammatory infiltrate in
glioblastoma (GBM). However, whether there are differences in their representation and …

[HTML][HTML] Molecular heterogeneity and immunosuppressive microenvironment in glioblastoma

S DeCordova, A Shastri, AG Tsolaki, H Yasmin… - Frontiers in …, 2020 - frontiersin.org
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a poor
prognosis, despite surgical resection combined with radio-and chemotherapy. The major …

[HTML][HTML] Cumulative Scoring systems and nomograms for predicating survival in patients with glioblastomas: a study based on peripheral inflammatory markers

C Yang, T Lan, Y Wang, WH Huang, SM Li, J Li… - Frontiers in …, 2022 - frontiersin.org
Inflammation is a hallmark of cancers. The purpose of the present study was to evaluate the
prognostic potential of hematological inflammatory markers in glioblastoma multiforme …