Antibody-mediated disruption of the annexin-V antithrombotic shield: a new mechanism for thrombosis in the antiphospholipid syndrome

JH Rand, XX Wu - Thrombosis and haemostasis, 1999 - thieme-connect.com
The antiphospholipid (aPL) syndrome is a condition that manifests in patients as vascular
thromboembolism or recurrent pregnancy loss together with laboratory evidence for the …

The pathogenic role of annexin-V in the antiphospholipid syndrome

JH Rand - Current Rheumatology Reports, 2000 - Springer
The antiphospholipid antibody syndrome is an autoimmune condition in which venous or
arterial thrombosis and recurrent pregnancy losses occur in patients having serologic …

Antiphospholipid antibodies accelerate plasma coagulation by inhibiting annexin-V binding to phospholipids: a “lupus procoagulant” phenomenon

JH Rand, XX Wu, HAM Andree… - Blood, The Journal …, 1998 - ashpublications.org
The antiphospholipid syndrome is a thrombophilic condition marked by antibodies that
recognize anionic phospholipid-protein cofactor complexes. We recently reported that …

Antiphospholipid antibody-mediated disruption of the annexin-V antithrombotic shield: a thrombogenic mechanism for the antiphospholipid syndrome

JH Rand - Journal of autoimmunity, 2000 - Elsevier
The mechanism (s) for thrombosis and pregnancy losses in the anti-phospholipid antibody
syndrome have not yet been established. Annexin-V is an anionic phospholipid-binding …

[HTML][HTML] Pathophysiology of antiphospholipid syndrome

D Green - Thrombosis and Haemostasis, 2022 - thieme-connect.com
The antiphospholipid syndrome is characterized by antibodies directed against
phospholipid-binding proteins and phospholipids attached to cell membrane receptors …

Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy …

JH Rand, XX Wu, AS Quinn, PP Chen… - The American journal of …, 2003 - Elsevier
The antiphospholipid (aPL) syndrome is an autoimmune condition that is marked by
recurrent pregnancy losses and/or systemic vascular thrombosis in patients who have …

Antiphospholipid antibody syndrome: new insights on thrombogenic mechanisms

JH Rand - The American journal of the medical sciences, 1998 - Elsevier
The anti phospholipid antibody syndrome is a thrombophilic condition manifested by
vascular thrombosis or recurrent pregnancy loss together with the presence of antibodies …

Antibody-mediated interference with annexins in the antiphospholipid syndrome

JH Rand, XX Wu - Thrombosis research, 2004 - Elsevier
Targeting of the annexin A5 anticoagulant shield may be a significant mechanism for
thrombosis and pregnancy losses in APS. This may occur via high affinity antibodies that …

[HTML][HTML] Pregnancy loss in the antiphospholipid-antibody syndrome—a possible thrombogenic mechanism

JH Rand, XX Wu, HAM Andree… - … England Journal of …, 1997 - Mass Medical Soc
Background The mechanisms of vascular thrombosis and pregnancy loss in the
antiphospholipid-antibody syndrome are unknown. Levels of annexin V, a phospholipid …

Autoantibodies against the fibrinolytic receptor, annexin 2, in antiphospholipid syndrome

G Cesarman-Maus, NP Ríos-Luna, AB Deora, B Huang… - Blood, 2006 - ashpublications.org
The association of thrombosis and gestational morbidity with antiphospholipid antibodies is
termed antiphospholipid syndrome (APS). Annexin 2 (A2) is a profibrinolytic endothelial cell …