Inhibition of cancer cell growth by ruthenium complexes

J Iida, ET Bell-Loncella, ML Purazo, Y Lu… - Journal of translational …, 2016 - Springer
Background Previous studies suggest that certain transition metal complexes, such as
cisplatin, are efficacious for treating various cancer types, including ovarian, lung, and …

Ruthenium complexes: an emerging ground to the development of metallopharmaceuticals for cancer therapy

M Abid, F Shamsi, A Azam - Mini Reviews in Medicinal …, 2016 - ingentaconnect.com
GLOBOCAN 2012 estimates 14.1 million new cancer cases and 8.2 million cancer-related
deaths worldwide. Cancer is rapidly becoming a major public health concern in India as …

A review of ruthenium complexes activities on breast cancer cells

CP Popolin, MR Cominetti - Mini Reviews in Medicinal …, 2017 - ingentaconnect.com
Background: Cancer is one of the main causes of death worldwide. Breast cancer is the
most prevalent type of cancer in women and the leading cause of cancer deaths due to its …

The development of anticancer ruthenium (II) complexes: from single molecule compounds to nanomaterials

L Zeng, P Gupta, Y Chen, E Wang, L Ji… - Chemical Society …, 2017 - pubs.rsc.org
Cancer is rapidly becoming the top killer in the world. Most of the FDA approved anticancer
drugs are organic molecules, while metallodrugs are very scarce. The advent of the first …

Ruthenium complexes as anticancer agents

I Kostova - Current medicinal chemistry, 2006 - ingentaconnect.com
Cancer is one of the major cases of death in the world. Current treatment of cancer is limited
to surgery, radiotherapy, and the use of cytotoxic agents, despite their well known side …

Cytotoxicity and anti-tumor effects of new ruthenium complexes on triple negative breast cancer cells

CP Popolin, JPB Reis, AB Becceneri, AE Graminha… - PLoS …, 2017 - journals.plos.org
Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype. The
high rate of metastasis associated to the fact that these cells frequently display multidrug …

Ruthenium (II) complexes with N, O-chelating proline and threonine ligands cause selective cytotoxicity by the induction of genomic instability, cell cycle arrest and …

IH de Sousa, VNS Campos, AAM Vale… - Toxicology in Vitro, 2020 - Elsevier
Ruthenium complexes are being considered as novel chemotherapeutic alternatives for
cancer treatment. In our study, we assessed the antitumoral activities of novel ruthenium …

Organoruthenium (II)-arene complexes: Structural building blocks for anticancer drug discovery

MJ Chow, WH Ang - … and organometallic transition metal complexes with …, 2017 - Elsevier
There has been much interest in the development of transition metal-based complexes for
cancer therapy fueled by the success of cisplatin, a platinum (II) chemotherapeutic agent, in …

Ruthenium complexes as potential cancer cell growth inhibitors for targeted chemotherapy

S Katheria - ChemistrySelect, 2022 - Wiley Online Library
The effective clinical use of the three generation platinum anticancer drugs, cisplatin,
carboplatin, and oxaliplatin, has sparked interest in metallodrugs; however, drug resistance …

Development of novel ruthenium (ii)–arene complexes displaying potent anticancer effects in glioblastoma cells

P Kumar, I Mondal, R Kulshreshtha, AK Patra - Dalton Transactions, 2020 - pubs.rsc.org
Glioblastomas (GBs) are highly aggressive and malignant brain tumors, which are highly
resistant to conventional multimodal treatments, leading to their abysmal prognosis. Herein …