[HTML][HTML] SA inhibits complex III activity to generate reactive oxygen species and thereby induces GA overproduction in Ganoderma lucidum

R Liu, P Cao, A Ren, S Wang, T Yang, T Zhu, L Shi… - Redox Biology, 2018 - Elsevier
Ganoderma lucidum has high commercial value because it produces many active
compounds, such as ganoderic acids (GAs). Salicylic acid (SA) was previously reported to …

Cross talk between nitric oxide and calcium-calmodulin regulates ganoderic acid biosynthesis in Ganoderma lucidum under heat stress

R Liu, L Shi, T Zhu, T Yang, A Ren, J Zhu… - Applied and …, 2018 - Am Soc Microbiol
We previously reported that high temperature impacts ganoderic acid (GA) biosynthesis in
Ganoderma lucidum via Ca2+. Therefore, to further understand the signal-regulating …

Effect of solid-medium coupled with reactive oxygen species on ganoderic acid biosynthesis and MAP kinase phosphorylation in Ganoderma lucidum

BJ You, WT Chang, KR Chung, YH Kuo… - Food research …, 2012 - Elsevier
Ganoderma lucidum is used as a functional food and medicinal mushroom in Asia.
Biosynthesis of its active ingredients, the ganoderic acids (GAs), together with signal …

Alternative oxidase impacts ganoderic acid biosynthesis by regulating intracellular ROS levels in Ganoderma lucidum

DK Shi, J Zhu, ZH Sun, G Zhang, R Liu… - …, 2017 - microbiologyresearch.org
The alternative oxidase (AOX), which forms a branch of the mitochondrial respiratory
electron transport pathway, functions to sustain electron flux and alleviate reactive oxygen …

The regulation of methyl jasmonate on hyphal branching and GA biosynthesis in Ganoderma lucidum partly via ROS generated by NADPH oxidase

L Shi, L Gong, X Zhang, A Ren, T Gao… - Fungal Genetics and …, 2015 - Elsevier
Ganoderma lucidum is one of the best known medicinal basidiomycetes because it
produces many pharmacologically active compounds, and methyl jasmonate (MeJA) was …

Effects of glutamate oxaloacetate transaminase on reactive oxygen species in Ganoderma lucidum

H Liu, J Qiao, J Shangguan, J Zhu - Applied Microbiology and …, 2023 - Springer
Nitrogen metabolism can regulate mycelial growth and secondary metabolism in
Ganoderma lucidum. As an important enzyme in intracellular amino acid metabolism …

Shedding light on the mechanisms underlying the environmental regulation of secondary metabolite ganoderic acid in Ganoderma lucidum using physiological and …

A Ren, L Shi, J Zhu, H Yu, A Jiang, H Zheng… - Fungal genetics and …, 2019 - Elsevier
The secondary metabolites of fungi are often produced at very low concentrations, and until
recently the regulatory mechanisms of secondary metabolite biosynthesis have been …

Integrated Proteomics and Metabolomics Analysis Provides Insights into Ganoderic Acid Biosynthesis in Response to Methyl Jasmonate in Ganoderma Lucidum

AL Jiang, YN Liu, R Liu, A Ren, HY Ma, LB Shu… - International Journal of …, 2019 - mdpi.com
Ganoderma lucidum is widely recognized as a medicinal basidiomycete. It was previously
reported that the plant hormone methyl jasmonate (MeJA) could induce the biosynthesis of …

Nitric oxide regulates ganoderic acid biosynthesis by the S‐nitrosylation of aconitase under heat stress in Ganoderma lucidum

R Liu, T Zhu, T Yang, Z Yang, A Ren… - Environmental …, 2021 - Wiley Online Library
Nitric oxide (NO) is an important signalling molecule in stress response of organisms. We
previously reported that NO decreases heat stress (HS)‐induced ganoderic acid (GA) …

Glsnf1-mediated metabolic rearrangement participates in coping with heat stress and influencing secondary metabolism in Ganoderma lucidum

Y Hu, W Xu, S Hu, L Lian, J Zhu, A Ren, L Shi… - Free Radical Biology …, 2020 - Elsevier
The AMP-activated protein kinase (AMPK)/Sucrose-nonfermenting serine-threonine protein
kinase 1 (Snf1) plays an important role in metabolic remodelling in response to energy …