[HTML][HTML] Enhanced Ganoderic Acids Accumulation and Transcriptional Responses of Biosynthetic Genes in Ganoderma lucidum Fruiting Bodies by Elicitation …

L Meng, X Bai, S Zhang, M Zhang, S Zhou… - International Journal of …, 2019 - mdpi.com
Ganoderic acids (GAs) are a type of highly oxygenated lanostane-type triterpenoids that are
responsible for the pharmacological activities of Ganoderma lucidum. They have been …

Heat stress promotes the conversion of putrescine to spermidine and plays an important role in regulating ganoderic acid biosynthesis in Ganoderma lucidum

Y Tao, X Han, A Ren, J Li, H Song, B Xie… - Applied Microbiology and …, 2021 - Springer
Heat stress (HS) is inescapable environmental stress that can induce the production of
ganoderic acids (GAs) in Ganoderma lucidum. Our previous studies found that putrescine …

Triterpenoid biosynthesis and the transcriptional response elicited by nitric oxide in submerged fermenting Ganoderma lucidum

L Gu, X Zhong, D Lian, Y Zheng, H Wang, X Liu - Process Biochemistry, 2017 - Elsevier
Ganoderic triterpenoid (GT) is a promising anti-tumour constituent in Ganoderma lucidum.
The aim of this study was to investigate induction by and a possible signalling mechanism of …

[HTML][HTML] Profiling and Quantifying Differential Gene Transcription Provide Insights into Ganoderic Acid Biosynthesis in Ganoderma lucidum in Response to Methyl …

A Ren, MJ Li, L Shi, DS Mu, AL Jiang, Q Han… - PloS one, 2013 - journals.plos.org
Ganoderma lucidum is a mushroom with traditional medicinal properties that has been
widely used in China and other countries in Eastern Asia. Ganoderic acids (GA) produced …

Transcript and metabolite alterations increase ganoderic acid content in Ganoderma lucidum using acetic acid as an inducer

A Ren, XB Li, ZG Miao, L Shi, AL Jaing, MW Zhao - Biotechnology letters, 2014 - Springer
Acetic acid at 5–8 mM increased ganoderic acid (GA) accumulation in Ganoderma lucidum.
After optimization by the response surface methodology, the GA content reached 5.5/100 mg …

Methyl jasmonate induces ganoderic acid biosynthesis in the basidiomycetous fungus Ganoderma lucidum

A Ren, L Qin, L Shi, X Dong, YX Li, MW Zhao - Bioresource technology, 2010 - Elsevier
This is the first time study to assess the novel use of methyl jasmonate (MeJA) to elicit
ganoderic acid (GA) biosynthesis in Ganoderma lucidum and the resulting experiments …

Membrane fluidity is involved in the regulation of heat stress induced secondary metabolism in Ganoderma lucidum

YN Liu, TJ Zhang, XX Lu, BL Ma, A Ren… - Environmental …, 2017 - Wiley Online Library
Ganoderma lucidum has become a potential model system for evaluating how
environmental factors regulate the secondary metabolism of basidiomycetes. Heat stress …

Regulation of glutamine synthetase activity by transcriptional and posttranslational modifications negatively influences ganoderic acid biosynthesis in Ganoderma …

J Zhu, S Song, Z Sun, L Lian, L Shi… - Environmental …, 2021 - Wiley Online Library
Glutamine synthetase (GS), a central nitrogen metabolic enzyme, plays important roles in
the nitrogen regulation network and secondary metabolism in fungi. However, the …

[HTML][HTML] Heat stress-induced reactive oxygen species participate in the regulation of HSP expression, hyphal branching and ganoderic acid biosynthesis in …

R Liu, X Zhang, A Ren, DK Shi, L Shi, J Zhu… - Microbiological …, 2018 - Elsevier
Heat stress (HS) is an important environmental factor that affects the growth and metabolism
of edible fungi, but the molecular mechanism of the heat stress response (HSR) remains …

Biosynthesis of a ganoderic acid in Saccharomyces cerevisiae by expressing a cytochrome P450 gene from Ganoderma lucidum

WF Wang, H Xiao, JJ Zhong - Biotechnology and …, 2018 - Wiley Online Library
Ganoderic acid (GA), a triterpenoid from the traditional Chinese medicinal higher fungus
Ganoderma lucidum, possesses antitumor and other significant pharmacological activities …