Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress

C Fox, Z Merali, C Harrison - Behavioural brain research, 2006 - Elsevier
Environmental enrichment (EE) has beneficial neurobiological, physiological and behavioral
effects. The purpose of the present paper is to review the animal research literature …

Environmental enrichment protects against stress-induced anxiety: Role of glucocorticoid receptor, ERK, and CREB signaling in the basolateral amygdala

LS Novaes, NB Dos Santos, RFP Batalhote… - …, 2017 - Elsevier
Environmental enrichment (EE) is an experimental animal model that enhances an animal's
opportunity to interact with sensory, motor, and social stimuli, compared to standard …

The impact of environmental enrichment in laboratory rats—behavioural and neurochemical aspects

J Simpson, JP Kelly - Behavioural brain research, 2011 - Elsevier
The provision of environmental enrichment (EE) for laboratory rats is recommended in
European guidelines governing laboratory animal welfare. It is believed the EE …

Enduring effects of environmental enrichment from weaning to adulthood on pituitary-adrenal function, pre-pulse inhibition and learning in male and female rats

Y Pena, M Prunell, D Rotllant, A Armario… - …, 2009 - Elsevier
Environmental enrichment (EE) increases stimulation and provides richer sensory, cognitive
and motor opportunities through the interaction with the social and physical environment. EE …

Differential impact of stress and environmental enrichment on corticolimbic circuits

MA Smail, BL Smith, N Nawreen, JP Herman - … biochemistry and behavior, 2020 - Elsevier
Stress exposure can produce profound changes in physiology and behavior that can impair
health and well-being. Of note, stress exposure is linked to anxiety disorders and depression …

Combined pre-and postnatal environmental enrichment programs the HPA axis differentially in male and female rats

L Welberg, KV Thrivikraman, PM Plotsky - Psychoneuroendocrinology, 2006 - Elsevier
Experimental environmental enrichment (EE) is usually applied in adulthood or immediately
after weaning, with robust effects on physiology and behaviour. To investigate the effects of …

Environmental enrichment in mice decreases anxiety, attenuates stress responses and enhances natural killer cell activity

N Benaroya‐Milshtein, N Hollander… - European Journal of …, 2004 - Wiley Online Library
The importance of environment in the regulation of brain, behaviour and physiology has
long been recognized in biological, social and medical sciences. Animals maintained under …

Environmental enrichment as a positive behavioral intervention across the lifespan

P Sampedro-Piquero, A Begega - Current neuropharmacology, 2017 - ingentaconnect.com
Background: In recent decades, the interest in behavioral interventions has been growing
due to the higher prevalence of age-related cognitive impairments. Hence, behavioral …

The relative benefits of environmental enrichment on learning and memory are greater when stressed: A meta-analysis of interactions in rodents

EL Macartney, M Lagisz, S Nakagawa - Neuroscience & Biobehavioral …, 2022 - Elsevier
Abstract Environmental enrichment (“EE”) is expected to alleviate the negative effects of
stress on cognitive performance. However, there are complexities associated with …

Environmental enrichment effects after early stress on behavior and functional brain networks in adult rats

H González-Pardo, JL Arias, G Vallejo, NM Conejo - PloS one, 2019 - journals.plos.org
Early life stress is associated with long-term and pervasive adverse effects on
neuroendocrine development, affecting normal cognitive and emotional development …