Although nephrotic-range proteinuria and progressive azotemia are unequivocal indications
of disordered glomerular function in patients with long-standing insulin-dependent diabetes …

More than half a century ago, Cambier [1] made the seemingly paradoxical observation that
diabetics, a group well represented in contemporary hemodialysis units, frequently exhibit …

Kidney disease in patients with type I diabetes is characterized by a remarkably long
interval, usually lo-20 years, from onset of diabetes to appearance of clinical nephropathy …

Evidence in man clearly demonstrates the dynamic nature of diabetic glomerulopathy, even
very early in the disease. Osterby and Gundersen (1) documented increased glomerular …

Diabetic nephropathy develops in only a subgroup of patients affected by type 1 diabetes.
Once established, this complication is quite difficult to control, and consequently its …

Clinical diabetic nephropathy in man is the consequence of the development of a specific
constellation of glomerular, tubular, vascular, and interstitial structural abnormalities …

Hyperfiltration is a very characteristic feature in insulin-dependent diabetes. Hyperfiltration is
to some extent associated with long-term glycemic control but the correlation is not very …

Renal failure is a complication of diabetes mellitus ultimately affecting approximately 45% of
insulindependent patients.'Its onset is heralded by the development of dipstix positive …

Dear Sir, While an increased glomerular filtration rate (GFR) is a well recognised feature of
early Type 1 (insulin-dependent) diabetes in humans [1, 2] its significance as a risk factor for …

Renal lesions constitute a major factor in the morbidity and mortality of diabetes mellitus;
however, the mechanisms underlying the development of diabetic glomerulopathy remain …