[HTML][HTML] Engineered procyanidin-Fe nanoparticle alleviates intestinal inflammation through scavenging ROS and altering gut microbiome in colitis mice

Y Chang, X Wu, S Lu, J Du, Y Long, Y Zhu… - Frontiers in …, 2023 - frontiersin.org
Inflammatory bowel disease (IBD) is an idiopathic chronic inflammatory bowel disease
characterized by inflammation, intestinal barrier injury, and imbalance of gut microbiota …

[HTML][HTML] Orally biomimetic metal-phenolic nanozyme with quadruple safeguards for intestinal homeostasis to ameliorate ulcerative colitis

Y Zhu, X Huang, Z Deng, T Bai, B Gao, C Xu… - Journal of …, 2024 - Springer
Background Ulcerative colitis (UC) is defined by persistent inflammatory processes within
the gastrointestinal tract of uncertain etiology. Current therapeutic approaches are limited in …

Redox-active nanoparticles for inflammatory bowel disease

Q Ren, S Sun, XD Zhang - Nano Research, 2021 - Springer
Homeostasis of gut microbiota is extremely essential for maintaining nutrient metabolism
and regulating immunological function. The increasing evidence suggests that inflammatory …

ROS Scavenging and inflammation-directed polydopamine nanoparticles regulate gut immunity and flora therapy in inflammatory bowel disease

M Bao, K Wang, J Li, Y Li, H Zhu, M Lu, Y Zhang… - Acta Biomaterialia, 2023 - Elsevier
Dysfunction of the intestinal mucosal immune system and dysbiosis of the intestinal
microflora can induce inflammatory bowel disease. However, drug-mediated clinical …

[HTML][HTML] A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease

F Zeng, Y Shi, C Wu, J Liang, Q Zhong, K Briley… - Journal of …, 2022 - Springer
Inflammatory bowel disease (IBD) is an incurable disease of the gastrointestinal tract with a
lack of effective therapeutic strategies. The proinflammatory microenvironment plays a …

Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease

Q Hu, J Li, T Wang, X Xu, Y Duan, Y Jin - ACS nano, 2024 - ACS Publications
Inflammatory bowel diseases (IBDs) refer to multifaceted disorders in the intestinal
microenvironment and microbiota homeostasis. In view of the broad bioactivity and high …

Reactive Oxygen Species‐Activated CO Versatile Nanomedicine with Innate Gut Immune and Microbiome Remodeling Effects for Treating Inflammatory Bowel …

Y Zeng, M Fan, Q Zhou, D Chen, T Jin… - Advanced Functional …, 2023 - Wiley Online Library
Abnormal activation of the gut mucosal immune system and a highly dysregulated gut
microbiota play essential roles in the progression of inflammatory bowel disease (IBD). The …

Metal polyphenol network/cerium oxide artificial enzymes therapeutic nanoplatform for MRI/CT-aided intestinal inflammation management

Z Deng, W Ma, C Ding, C Wei, B Gao, Y Zhu, Y Zhang… - Nano Today, 2023 - Elsevier
Intestinal inflammation, such as ulcerative colitis (UC), is a condition in which there is
chronic or recurring inflammation of the gastrointestinal tract. Designing safe, effective, and …

An oral nano-antioxidant for targeted treatment of inflammatory bowel disease by regulating macrophage polarization and inhibiting ferroptosis of intestinal cells

J Yang, Y Bai, S Shen, X Tao, C Ma, B Fu, Q Dai… - Chemical Engineering …, 2023 - Elsevier
Inflammatory bowel disease (IBD) is a chronic inflammatory disease that characterized by
excessive reactive oxygen species (ROS) and high ferroptosis. The ROS plays an essential …

[HTML][HTML] Enzyme-like biomimetic oral-agent enabling modulating gut microbiota and restoring redox homeostasis to treat inflammatory bowel disease

Z Shi, X Li, J Chen, Z Dai, Y Zhu, T Wu, Q Liu, H Qin… - Bioactive Materials, 2024 - Elsevier
Reactive oxygen species (ROS), immune dysregulation-induced inflammatory outbreaks
and microbial imbalance play critical roles in the development of inflammatory bowel …