Background Bladder cancer is one of the most common malignant tumors of the urinary
system and is associated with a poor prognosis once invasion and distant metastases occur …

Urinary bladder cancer (UBC) patients at muscle invasive stage have poor clinical outcome,
due to high propensity for metastasis. Cancer-associated fibroblasts (CAFs), one of the …

Abstract Background Cancer-associated fibroblasts (CAFs), activated by tumour cells, are
the predominant type of stromal cells in cancer tissue and play an important role in …

Bladder cancer (BC) is the most common urinary system malignancy worldwide. However,
the molecular mechanisms underlying its progression remain largely unexplored …

The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under
debate. To determine the function of TGF-β signaling in bladder cancer progression, we …

High recurrence rates and poor survival rates of metastatic bladder cancer emphasize the
need for a drug that can prevent and/or treat bladder cancer progression and metastasis …

Bladder carcinoma (BC) recurrence is a major clinical challenge, and targeting the tumor
microenvironment (TME) is a promising therapy. However, the relationship between …

Epithelial–mesenchymal transitions (EMTs) are essential manifestations of epithelial cell
plasticity during tumor progression. Transforming growth factor-β (TGF-β) modulates …

Purpose: Bladder cancer treatment remains a major clinical challenge due to therapy
resistance and a high recurrence rate. Profiling intratumor heterogeneity can reveal the …

Objective. This work analyzes the role of versican (VCAN) on bladder cancer (BLCA).
Versican (VCAN) is a chondroitin sulfate proteoglycan which is important for tumorigenesis …