In cultured human glomerular epithelial cells (HGEC), 25 mM glucose resulted in decreased
expression of α3-, α2-, and β1-integrins and increased expression of α5-and αvβ3-integrins …

Background: Diabetic nephropathy, a kidney disease caused by diabetes, is the most
devastating and money-consuming complication in patients with diabetes throughout the …

Icariin has been shown to attenuate diabetic nephropathy in rats by decreasing transforming
growth factor‐β (TGF‐β) and type IV collagen expression, but its mode of action in …

Abstract Angiotensin II (Ang II) is known to play a pivotal role in the development of diabetic
nephropathy. However, the precise mechanism of Ang II-mediated effects on diabetic …

Excessive deposition of extracellular matrix (ECM) in the glomerulus contributed by
mesangial cells is the hallmark of diabetic nephropathy, eventually leading to …

The intrarenal renin-angiotensin system has been implicated in the pathogenesis of diabetic
nephropathy. This study investigates the mechanisms for glucose-induced increase in …

Aims/hypothesis Increased expression and decreased degradation of extracellular matrix
(ECM) proteins are key features of chronic diabetic complications. Fibronectin, a …

High ambient glucose exerts its injurious effects on renal cells through nonenzymatic and
enzymatic pathways, including altered signal transduction and upregulation of the …

Activation of renal signaling pathways indb/dbmice with type 2 diabetes. Background Altered
regulation of signaling pathways may contribute to the pathogenesis of renal disease. We …

Increase in protein synthesis contributes to kidney hypertrophy and matrix protein
accumulation in diabetes. We have previously shown that high glucose-induced matrix …